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• W3000310863 endingPage "F505" @default.
• W3000310863 startingPage "F496" @default.
• W3000310863 abstract "Urethral smooth muscle (USM) generates tone to prevent urine leakage from the bladder during filling. USM tone has been thought to be a voltage-dependent process, relying on Ca 2+ influx via voltage-dependent Ca 2+ channels in USM cells, modulated by the activation of Ca 2+ -activated Cl − channels encoded by Ano1. However, recent findings in the mouse have suggested that USM tone is voltage independent, relying on Ca 2+ influx through Orai channels via store-operated Ca 2+ entry (SOCE). We explored if this pathway also occurred in the pig using isometric tension recordings of USM tone. Pig USM strips generated myogenic tone, which was nearly abolished by the Ca v 1.2 channel antagonist nifedipine and the ATP-dependent K + channel agonist pinacidil. Pig USM tone was reduced by the Orai channel blocker GSK-7975A. Electrical field stimulation (EFS) led to phentolamine-sensitive contractions of USM strips. Contractions of pig USM were also induced by phenylephrine. Phenylephrine-evoked and EFS-evoked contractions of pig USM were reduced by ~50–75% by nifedipine and ~30% by GSK-7975A. Inhibition of Ano1 channels had no effect on tone or EFS-evoked contractions of pig USM. In conclusion, unlike the mouse, pig USM exhibited voltage-dependent tone and agonist/EFS-evoked contractions. Whereas SOCE plays a role in generating tone and agonist/neural-evoked contractions in both species, this dominates in the mouse. Tone and agonist/EFS-evoked contractions of pig USM are the result of Ca 2+ influx primarily through Ca v 1.2 channels, and no evidence was found supporting a role of Ano1 channels in modulating these mechanisms." @default.
• W3000310863 created "2020-01-23" @default.
• W3000310863 creator A5028080442 @default.
• W3000310863 creator A5039962039 @default.
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• W3000310863 date "2020-02-01" @default.
• W3000310863 modified "2023-09-23" @default.
• W3000310863 title "Contribution of Ca_v1.2 Ca²⁺ channels and store-operated Ca²⁺ entry to pig urethral smooth muscle contraction" @default.
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• W3000310863 doi "https://doi.org/10.1152/ajprenal.00514.2019" @default.
• W3000310863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31904286" @default.
• W3000310863 hasPublicationYear "2020" @default.
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