Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000327232> ?p ?o ?g. }
- W3000327232 endingPage "187" @default.
- W3000327232 startingPage "175" @default.
- W3000327232 abstract "Uveal melanoma (UM) is the most common malignant tumor of the eye. Recently, we have established that 46% of UM specimens express LHRH receptors. This finding supports the idea of a LHRH receptor-targeted therapy of UM patients. Cytotoxic analog of LHRH, AEZS-108 exhibits effective anti-cancer activity in LHRH-receptor positive cancers. AEZS-108 is a hybrid molecule, composed of a synthetic peptide carrier and the cytotoxic doxorubicin (DOX). In the present study, we investigated AEZS-108 induced cytotoxicity and the altered mRNA expression profile of regulatory factors related to angiogenesis and metastasis in LHRH receptor positive OCM3 cells. Our results show that AEZS-108 upregulates the expression of MASPIN/SERPINB5 tumor suppressor gene, which is downregulated in normal uvea and UM specimens independently from the LHRH receptor-ligand interaction. AEZS-108 also substantially downregulates hypoxia-inducible factor 1 alpha (HIF1A) expression. In order to investigate the mechanism of the induction of MASPIN by AEZS-108, OCM3 cells were treated with free DOX, D-Lys6 LHRH analog, or AEZS-108. qRT- PCR analysis revealed in OCM3 cells that AEZS-108 is a more potent inducer of MASPIN than free DOX. In conclusion, we show for the first time that AEZS-108 has a major impact in the regulation of angiogenesis thus plays a potential role in tumor suppression. Taken together, our results support the development of novel therapeutic strategies for UM focusing on LHRH receptors." @default.
- W3000327232 created "2020-01-23" @default.
- W3000327232 creator A5008707617 @default.
- W3000327232 creator A5008776450 @default.
- W3000327232 creator A5010437150 @default.
- W3000327232 creator A5014620776 @default.
- W3000327232 creator A5034016297 @default.
- W3000327232 creator A5036893975 @default.
- W3000327232 creator A5040610800 @default.
- W3000327232 creator A5068739269 @default.
- W3000327232 date "2020-01-14" @default.
- W3000327232 modified "2023-10-18" @default.
- W3000327232 title "The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma" @default.
- W3000327232 cites W1487152933 @default.
- W3000327232 cites W1493097681 @default.
- W3000327232 cites W1527820373 @default.
- W3000327232 cites W1722184079 @default.
- W3000327232 cites W1971366285 @default.
- W3000327232 cites W1983842587 @default.
- W3000327232 cites W1984408402 @default.
- W3000327232 cites W1988045720 @default.
- W3000327232 cites W2002181841 @default.
- W3000327232 cites W2007105443 @default.
- W3000327232 cites W2012080977 @default.
- W3000327232 cites W2017118651 @default.
- W3000327232 cites W2018032989 @default.
- W3000327232 cites W2018172717 @default.
- W3000327232 cites W2024667537 @default.
- W3000327232 cites W2028576334 @default.
- W3000327232 cites W2031261947 @default.
- W3000327232 cites W2036199674 @default.
- W3000327232 cites W2036310457 @default.
- W3000327232 cites W2037859708 @default.
- W3000327232 cites W2040577381 @default.
- W3000327232 cites W2047332601 @default.
- W3000327232 cites W2049509937 @default.
- W3000327232 cites W2059039824 @default.
- W3000327232 cites W2060143945 @default.
- W3000327232 cites W2075790098 @default.
- W3000327232 cites W2083469330 @default.
- W3000327232 cites W2083975216 @default.
- W3000327232 cites W2084688538 @default.
- W3000327232 cites W2094599840 @default.
- W3000327232 cites W2099989178 @default.
- W3000327232 cites W2101085574 @default.
- W3000327232 cites W2122658391 @default.
- W3000327232 cites W2128302079 @default.
- W3000327232 cites W2128635872 @default.
- W3000327232 cites W2129104001 @default.
- W3000327232 cites W2130992263 @default.
- W3000327232 cites W2136428790 @default.
- W3000327232 cites W2147849744 @default.
- W3000327232 cites W2161525530 @default.
- W3000327232 cites W2162492382 @default.
- W3000327232 cites W2162971220 @default.
- W3000327232 cites W2165681639 @default.
- W3000327232 cites W2167733127 @default.
- W3000327232 cites W2237017536 @default.
- W3000327232 cites W2292802983 @default.
- W3000327232 cites W2294062060 @default.
- W3000327232 cites W2413804005 @default.
- W3000327232 cites W2468517092 @default.
- W3000327232 cites W2789506451 @default.
- W3000327232 cites W2885321426 @default.
- W3000327232 cites W2950793465 @default.
- W3000327232 cites W2953090895 @default.
- W3000327232 cites W2957117793 @default.
- W3000327232 cites W4293247451 @default.
- W3000327232 doi "https://doi.org/10.18632/oncotarget.27431" @default.
- W3000327232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6968782" @default.
- W3000327232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32010430" @default.
- W3000327232 hasPublicationYear "2020" @default.
- W3000327232 type Work @default.
- W3000327232 sameAs 3000327232 @default.
- W3000327232 citedByCount "8" @default.
- W3000327232 countsByYear W30003272322020 @default.
- W3000327232 countsByYear W30003272322021 @default.
- W3000327232 countsByYear W30003272322022 @default.
- W3000327232 crossrefType "journal-article" @default.
- W3000327232 hasAuthorship W3000327232A5008707617 @default.
- W3000327232 hasAuthorship W3000327232A5008776450 @default.
- W3000327232 hasAuthorship W3000327232A5010437150 @default.
- W3000327232 hasAuthorship W3000327232A5014620776 @default.
- W3000327232 hasAuthorship W3000327232A5034016297 @default.
- W3000327232 hasAuthorship W3000327232A5036893975 @default.
- W3000327232 hasAuthorship W3000327232A5040610800 @default.
- W3000327232 hasAuthorship W3000327232A5068739269 @default.
- W3000327232 hasBestOaLocation W30003272321 @default.
- W3000327232 hasConcept C121608353 @default.
- W3000327232 hasConcept C170493617 @default.
- W3000327232 hasConcept C185592680 @default.
- W3000327232 hasConcept C203014093 @default.
- W3000327232 hasConcept C2777658100 @default.
- W3000327232 hasConcept C2779013556 @default.
- W3000327232 hasConcept C2780394083 @default.
- W3000327232 hasConcept C502942594 @default.
- W3000327232 hasConcept C54355233 @default.
- W3000327232 hasConcept C55493867 @default.