FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000333609> ?p ?o ?g. }

• W3000333609 endingPage "442" @default.
• W3000333609 startingPage "432" @default.
• W3000333609 abstract "Background: Hashimoto's thyroiditis (HT) is a common autoimmune disease of unknown origin. However, viral infections have been implicated as triggers for autoimmunity. Human leukocyte antigen (HLA) class I presents antigens to circulating immune cells and plays a crucial role in the defense against viral infections. This study aimed to investigate the presence of enterovirus and HLA class I expression in one of the largest HT thyroid tissue cohorts to date. In addition, viral receptors and viral immune response proteins were examined. Methods: Thyroid tissue samples from 46 HT patients were obtained using core needle biopsy. Thyroid tissue collected during neck surgery for other reasons than thyroid autoimmunity served as controls. Standard immunohistochemistry on formalin-fixed, paraffin-embedded tissue samples were used to detect HLA class I, enteroviral capsid protein 1 (VP1), and coxsackie and adenovirus receptor (CAR) in thyroid cells. A subset of the samples was examined with combined immunofluorescence staining for signal transducer and activator of transcription 1 (STAT1) and protein kinase R (PKR). Results: Significantly more HLA class I-positive samples were found in the HT group (31 out of 46 [67.4%]) than in the control group (5 out of 24 [20.8%]) (p < 0.001). Moreover, the semiquantitative score assessing the grade of HLA class I expression was significantly higher in the HT group (3.9 ± 3.1) than in the control group (0.5 ± 0.9) (p < 0.001). In addition, STAT1 was colocalized with HLA class I, and PKR and VP1 were also found and were colocalized together. VP1 was detected in both controls and the HT samples, with slightly more VP1+ thyroid cells in the HT samples (20.1% ± 16.4%) than in controls (14.9% ± 10.5%). Finally, the presence of CAR in thyroid cells was confirmed. Conclusion: The current study confirmed that HLA class I hyperexpression is a defining feature of HT. Thyroid cells express CAR, thus making them susceptible to enterovirus infection. The colocalization of HLA class I with STAT1 and VP1 with PKR indicates an intracellular, antiviral host response. These findings support the concept of a firm link between viral infection and autoimmune thyroid diseases." @default.
• W3000333609 created "2020-01-23" @default.
• W3000333609 creator A5001736921 @default.
• W3000333609 creator A5006823994 @default.
• W3000333609 creator A5020408351 @default.
• W3000333609 creator A5035490035 @default.
• W3000333609 creator A5058034008 @default.
• W3000333609 creator A5090414747 @default.
• W3000333609 date "2020-03-01" @default.
• W3000333609 modified "2023-09-25" @default.
• W3000333609 title "Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis" @default.
• W3000333609 cites W1009820876 @default.
• W3000333609 cites W1542058436 @default.
• W3000333609 cites W1554772391 @default.
• W3000333609 cites W1644368017 @default.
• W3000333609 cites W1759060244 @default.
• W3000333609 cites W1789678333 @default.
• W3000333609 cites W1892496998 @default.
• W3000333609 cites W1964980715 @default.
• W3000333609 cites W1992659504 @default.
• W3000333609 cites W2003479771 @default.
• W3000333609 cites W2005127084 @default.
• W3000333609 cites W2005935881 @default.
• W3000333609 cites W2006629564 @default.
• W3000333609 cites W2012588545 @default.
• W3000333609 cites W2014090782 @default.
• W3000333609 cites W2016129825 @default.
• W3000333609 cites W2021847833 @default.
• W3000333609 cites W2033845186 @default.
• W3000333609 cites W2042433752 @default.
• W3000333609 cites W2052657210 @default.
• W3000333609 cites W2066396292 @default.
• W3000333609 cites W2068047918 @default.
• W3000333609 cites W2079193933 @default.
• W3000333609 cites W2079357798 @default.
• W3000333609 cites W2082854150 @default.
• W3000333609 cites W2088830438 @default.
• W3000333609 cites W2102872217 @default.
• W3000333609 cites W2110458118 @default.
• W3000333609 cites W2122506044 @default.
• W3000333609 cites W2126981851 @default.
• W3000333609 cites W2127354797 @default.
• W3000333609 cites W2130290882 @default.
• W3000333609 cites W2135177247 @default.
• W3000333609 cites W2136690547 @default.
• W3000333609 cites W2144658123 @default.
• W3000333609 cites W2159564423 @default.
• W3000333609 cites W2174565602 @default.
• W3000333609 cites W2460768354 @default.
• W3000333609 cites W2500142263 @default.
• W3000333609 cites W2511194730 @default.
• W3000333609 cites W2513957711 @default.
• W3000333609 cites W2547868892 @default.
• W3000333609 cites W2550389483 @default.
• W3000333609 cites W2560278821 @default.
• W3000333609 cites W2883165621 @default.
• W3000333609 cites W2891870896 @default.
• W3000333609 cites W2914264295 @default.
• W3000333609 cites W4246260688 @default.
• W3000333609 cites W4251983496 @default.
• W3000333609 cites W1866204626 @default.
• W3000333609 doi "https://doi.org/10.1089/thy.2019.0607" @default.
• W3000333609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31910110" @default.
• W3000333609 hasPublicationYear "2020" @default.
• W3000333609 type Work @default.
• W3000333609 sameAs 3000333609 @default.
• W3000333609 citedByCount "8" @default.
• W3000333609 countsByYear W30003336092020 @default.
• W3000333609 countsByYear W30003336092021 @default.
• W3000333609 countsByYear W30003336092022 @default.
• W3000333609 countsByYear W30003336092023 @default.
• W3000333609 crossrefType "journal-article" @default.
• W3000333609 hasAuthorship W3000333609A5001736921 @default.
• W3000333609 hasAuthorship W3000333609A5006823994 @default.
• W3000333609 hasAuthorship W3000333609A5020408351 @default.
• W3000333609 hasAuthorship W3000333609A5035490035 @default.
• W3000333609 hasAuthorship W3000333609A5058034008 @default.
• W3000333609 hasAuthorship W3000333609A5090414747 @default.
• W3000333609 hasBestOaLocation W30003336092 @default.
• W3000333609 hasConcept C126322002 @default.
• W3000333609 hasConcept C147483822 @default.
• W3000333609 hasConcept C188280979 @default.
• W3000333609 hasConcept C203014093 @default.
• W3000333609 hasConcept C2778696486 @default.
• W3000333609 hasConcept C2780130043 @default.
• W3000333609 hasConcept C526584372 @default.
• W3000333609 hasConcept C71924100 @default.
• W3000333609 hasConcept C86803240 @default.
• W3000333609 hasConcept C8891405 @default.
• W3000333609 hasConceptScore W3000333609C126322002 @default.
• W3000333609 hasConceptScore W3000333609C147483822 @default.
• W3000333609 hasConceptScore W3000333609C188280979 @default.
• W3000333609 hasConceptScore W3000333609C203014093 @default.
• W3000333609 hasConceptScore W3000333609C2778696486 @default.
• W3000333609 hasConceptScore W3000333609C2780130043 @default.
• W3000333609 hasConceptScore W3000333609C526584372 @default.
• W3000333609 hasConceptScore W3000333609C71924100 @default.
• W3000333609 hasConceptScore W3000333609C86803240 @default.

• next