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- W3000337564 abstract "Abstract Objectives To investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms. Methods Orthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI-MS. A potassium oxonate (PO) induced hyperuricemic mouse model was used to evaluate antihyperuricemia and nephroprotective effects of O. stamineus ethyl acetate extracts (OSE). Key findings Eight constituents from OSE were identified and OSE treatment ameliorated HUA by regulating key indicators of kidney dysfunction and xanthine oxidase, adenosine deaminase activity and urate transporters in hyperuricemic mice. Moreover, in renal histopathology analysis, OSE significantly alleviated kidney injury. Conclusions These findings demonstrate that OSE has antihyperuricemic and nephroprotective effects on PO-induced HUA mice and those results indicate that OSE could be a safe and effective agent or functional ingredient for treating HUA." @default.
- W3000337564 created "2020-01-23" @default.
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- W3000337564 date "2020-01-07" @default.
- W3000337564 modified "2023-10-14" @default.
- W3000337564 title "Antihyperuricemic and nephroprotective effects of extracts from <i>Orthosiphon stamineus</i> in hyperuricemic mice" @default.
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- W3000337564 doi "https://doi.org/10.1111/jphp.13222" @default.
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