Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000344538> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W3000344538 abstract "ABSTRACT Background Adjuvant chemotherapy following metastases resection of colorectal cancer is recommended although the benefit has not been clearly demonstrated in clinical trials. Methods We have performed a retrospective review of patients (pt) with hepatic and lung metastases treated with surgery and adjuvant chemotherapy in our institution, from January-96 to December-11. Results One hundred ninety one patients were identified. Patient characteristics: median age 62 years (23-81). Sex: 114 male (60%) 77 female (40%). Primary tumour location: colon 129 (67.5%) rectal 62 (32.5%). Metastases location: hepatic 143 (75%), lung 46 (24%) lung and hepatic 2 (1%). Primary tumour stage: I stage 2 (1%) II stage 50 (26%) III stage 87 (46%) IV stage 52 (27%). Adjuvant chemotherapy: 5-Fluorouracil + Leucovorin 70 (36.6%), Irinotecan-based 9 (4.7%) Oxaliplatin-based 112 (58.6%). Presurgical CEA: normal 146 pt (76%) increased 45 (24%). Number of metastases: one 87 pt (45%), two 65 (34%), three 18 pt (9%), more than three 21 pt (11%). Treatment compliance: 149 pt (78%) completed planned treatment; 42 pt (22%) did not complete it due to toxicity or progressive disease. Recurrence was diagnosed in 105 pt (55%). Surgery for relapsed disease was performed in 105 pt (38%). Median overall survival has not been reached, as only 77 pt have died. Estimated 5-years survival is 62%. Median progression free survival is 30 months. Significant factors for survival: sex (better female), node positive primary tumour, increased CEA, and more than 3 metastases. There were no differences between chemotherapy schedules. Conclusion Surgery of hepatic and lung metastases from colorectal cancer has a curative goal. Adjuvant chemotherapy could achieve an improvement of survival by decreasing recurrence rate. We must emphasize that patients included in this analysis have good prognostic factors so results should be interpreted with caution. Disclosure All authors have declared no conflicts of interest." @default.
- W3000344538 created "2020-01-23" @default.
- W3000344538 creator A5000783518 @default.
- W3000344538 creator A5001622789 @default.
- W3000344538 creator A5005212111 @default.
- W3000344538 creator A5012450305 @default.
- W3000344538 creator A5031541143 @default.
- W3000344538 creator A5037328196 @default.
- W3000344538 creator A5050111884 @default.
- W3000344538 creator A5056792472 @default.
- W3000344538 creator A5067691154 @default.
- W3000344538 creator A5080215451 @default.
- W3000344538 date "2012-09-01" @default.
- W3000344538 modified "2023-09-29" @default.
- W3000344538 title "Results of Adjuvant Chemotherapy after Hepatic and/or Lung Metastases Resection of Colorectal Cancer" @default.
- W3000344538 doi "https://doi.org/10.1016/s0923-7534(20)33098-2" @default.
- W3000344538 hasPublicationYear "2012" @default.
- W3000344538 type Work @default.
- W3000344538 sameAs 3000344538 @default.
- W3000344538 citedByCount "0" @default.
- W3000344538 crossrefType "journal-article" @default.
- W3000344538 hasAuthorship W3000344538A5000783518 @default.
- W3000344538 hasAuthorship W3000344538A5001622789 @default.
- W3000344538 hasAuthorship W3000344538A5005212111 @default.
- W3000344538 hasAuthorship W3000344538A5012450305 @default.
- W3000344538 hasAuthorship W3000344538A5031541143 @default.
- W3000344538 hasAuthorship W3000344538A5037328196 @default.
- W3000344538 hasAuthorship W3000344538A5050111884 @default.
- W3000344538 hasAuthorship W3000344538A5056792472 @default.
- W3000344538 hasAuthorship W3000344538A5067691154 @default.
- W3000344538 hasAuthorship W3000344538A5080215451 @default.
- W3000344538 hasBestOaLocation W30003445381 @default.
- W3000344538 hasConcept C121608353 @default.
- W3000344538 hasConcept C126322002 @default.
- W3000344538 hasConcept C141071460 @default.
- W3000344538 hasConcept C143998085 @default.
- W3000344538 hasConcept C146357865 @default.
- W3000344538 hasConcept C151730666 @default.
- W3000344538 hasConcept C2776694085 @default.
- W3000344538 hasConcept C2777714996 @default.
- W3000344538 hasConcept C2780259306 @default.
- W3000344538 hasConcept C2780962732 @default.
- W3000344538 hasConcept C526805850 @default.
- W3000344538 hasConcept C71924100 @default.
- W3000344538 hasConcept C86803240 @default.
- W3000344538 hasConcept C90924648 @default.
- W3000344538 hasConceptScore W3000344538C121608353 @default.
- W3000344538 hasConceptScore W3000344538C126322002 @default.
- W3000344538 hasConceptScore W3000344538C141071460 @default.
- W3000344538 hasConceptScore W3000344538C143998085 @default.
- W3000344538 hasConceptScore W3000344538C146357865 @default.
- W3000344538 hasConceptScore W3000344538C151730666 @default.
- W3000344538 hasConceptScore W3000344538C2776694085 @default.
- W3000344538 hasConceptScore W3000344538C2777714996 @default.
- W3000344538 hasConceptScore W3000344538C2780259306 @default.
- W3000344538 hasConceptScore W3000344538C2780962732 @default.
- W3000344538 hasConceptScore W3000344538C526805850 @default.
- W3000344538 hasConceptScore W3000344538C71924100 @default.
- W3000344538 hasConceptScore W3000344538C86803240 @default.
- W3000344538 hasConceptScore W3000344538C90924648 @default.
- W3000344538 hasLocation W30003445381 @default.
- W3000344538 hasOpenAccess W3000344538 @default.
- W3000344538 hasPrimaryLocation W30003445381 @default.
- W3000344538 hasRelatedWork W1995680367 @default.
- W3000344538 hasRelatedWork W2010186447 @default.
- W3000344538 hasRelatedWork W2077911314 @default.
- W3000344538 hasRelatedWork W2123034797 @default.
- W3000344538 hasRelatedWork W2136149949 @default.
- W3000344538 hasRelatedWork W2137522873 @default.
- W3000344538 hasRelatedWork W2145595177 @default.
- W3000344538 hasRelatedWork W2162169150 @default.
- W3000344538 hasRelatedWork W2171253554 @default.
- W3000344538 hasRelatedWork W2214142774 @default.
- W3000344538 hasRelatedWork W2259552630 @default.
- W3000344538 hasRelatedWork W2282183033 @default.
- W3000344538 hasRelatedWork W2336936215 @default.
- W3000344538 hasRelatedWork W2364923639 @default.
- W3000344538 hasRelatedWork W2384130033 @default.
- W3000344538 hasRelatedWork W2548348375 @default.
- W3000344538 hasRelatedWork W2786040819 @default.
- W3000344538 hasRelatedWork W2901484485 @default.
- W3000344538 hasRelatedWork W2903002959 @default.
- W3000344538 hasRelatedWork W2040905392 @default.
- W3000344538 isParatext "false" @default.
- W3000344538 isRetracted "false" @default.
- W3000344538 magId "3000344538" @default.
- W3000344538 workType "article" @default.