Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000365840> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3000365840 abstract "Multipotent mesenchymal stem cells (MSCs) have been investigated in autoimmune diseases such as rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. In this study, their immunosuppressive effects on peripheral blood mononuclear cells (PBMC) of RA patients were studied.Dental follicle stem cells (DFSCs) were isolated from follicle tissue in the orofacial region. Characterization and multipotency analyses were performed. Lymphocytes were isolated from peripheral venous blood of RA patients (n = 5) and healthy individuals (n = 5). DFSCs were preincubated with IFN-γ for 48 h. PBMCs of RA patients and healthy individuals were separately cultured with or without DFSCs for 72 h. After culture period, lymphocyte proliferation and viability, the frequency of CD4+ CD25+FoxP3+ T regulatory cells, IL-10 and TNF-α levels in the culture supernatants were measured via flow cytometry.Our results demonstrated that DFSCs suppressed proliferation of T lymphocytes by increasing the number of FoxP3 expressing CD4+CD25+ T regulatory cells and suppressed lymphocyte apoptosis in RA patients. Also, DFSCs reduced TNF-α cytokine secretion and upregulated IL-10 secreting cells.Such cells could potentially be a source for future immunomodulatory treatments of RA patients." @default.
- W3000365840 created "2020-01-23" @default.
- W3000365840 date "2019-01-01" @default.
- W3000365840 modified "2023-10-18" @default.
- W3000365840 title "IFN-? stimulated dental follicle mesenchymal stem cells regulate activated lymphocyte response in rheumatoid arthritis patients in vitro" @default.
- W3000365840 cites W1507624196 @default.
- W3000365840 cites W1564612499 @default.
- W3000365840 cites W1914199395 @default.
- W3000365840 cites W1917515270 @default.
- W3000365840 cites W1925130139 @default.
- W3000365840 cites W1978011938 @default.
- W3000365840 cites W1981359573 @default.
- W3000365840 cites W1981787940 @default.
- W3000365840 cites W1990497696 @default.
- W3000365840 cites W1995122819 @default.
- W3000365840 cites W2002325129 @default.
- W3000365840 cites W2009194913 @default.
- W3000365840 cites W2041570550 @default.
- W3000365840 cites W2071872861 @default.
- W3000365840 cites W2074526547 @default.
- W3000365840 cites W2104669609 @default.
- W3000365840 cites W2110345763 @default.
- W3000365840 cites W2110826367 @default.
- W3000365840 cites W2118268169 @default.
- W3000365840 cites W2144337206 @default.
- W3000365840 cites W2148830915 @default.
- W3000365840 cites W2155109530 @default.
- W3000365840 cites W2158734690 @default.
- W3000365840 cites W2560577160 @default.
- W3000365840 cites W2772090434 @default.
- W3000365840 doi "https://doi.org/10.3906/sag-1812-152" @default.
- W3000365840 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7520073" @default.
- W3000365840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31655532" @default.
- W3000365840 hasPublicationYear "2019" @default.
- W3000365840 type Work @default.
- W3000365840 sameAs 3000365840 @default.
- W3000365840 citedByCount "1" @default.
- W3000365840 countsByYear W30003658402023 @default.
- W3000365840 crossrefType "journal-article" @default.
- W3000365840 hasBestOaLocation W30003658402 @default.
- W3000365840 hasConcept C137061746 @default.
- W3000365840 hasConcept C142724271 @default.
- W3000365840 hasConcept C198826908 @default.
- W3000365840 hasConcept C202751555 @default.
- W3000365840 hasConcept C203014093 @default.
- W3000365840 hasConcept C2776090121 @default.
- W3000365840 hasConcept C2777575956 @default.
- W3000365840 hasConcept C2777761686 @default.
- W3000365840 hasConcept C2778690821 @default.
- W3000365840 hasConcept C2779727006 @default.
- W3000365840 hasConcept C28328180 @default.
- W3000365840 hasConcept C47794810 @default.
- W3000365840 hasConcept C553184892 @default.
- W3000365840 hasConcept C55493867 @default.
- W3000365840 hasConcept C71924100 @default.
- W3000365840 hasConcept C79484868 @default.
- W3000365840 hasConcept C86803240 @default.
- W3000365840 hasConcept C8891405 @default.
- W3000365840 hasConcept C95444343 @default.
- W3000365840 hasConceptScore W3000365840C137061746 @default.
- W3000365840 hasConceptScore W3000365840C142724271 @default.
- W3000365840 hasConceptScore W3000365840C198826908 @default.
- W3000365840 hasConceptScore W3000365840C202751555 @default.
- W3000365840 hasConceptScore W3000365840C203014093 @default.
- W3000365840 hasConceptScore W3000365840C2776090121 @default.
- W3000365840 hasConceptScore W3000365840C2777575956 @default.
- W3000365840 hasConceptScore W3000365840C2777761686 @default.
- W3000365840 hasConceptScore W3000365840C2778690821 @default.
- W3000365840 hasConceptScore W3000365840C2779727006 @default.
- W3000365840 hasConceptScore W3000365840C28328180 @default.
- W3000365840 hasConceptScore W3000365840C47794810 @default.
- W3000365840 hasConceptScore W3000365840C553184892 @default.
- W3000365840 hasConceptScore W3000365840C55493867 @default.
- W3000365840 hasConceptScore W3000365840C71924100 @default.
- W3000365840 hasConceptScore W3000365840C79484868 @default.
- W3000365840 hasConceptScore W3000365840C86803240 @default.
- W3000365840 hasConceptScore W3000365840C8891405 @default.
- W3000365840 hasConceptScore W3000365840C95444343 @default.
- W3000365840 hasLocation W30003658401 @default.
- W3000365840 hasLocation W30003658402 @default.
- W3000365840 hasLocation W30003658403 @default.
- W3000365840 hasOpenAccess W3000365840 @default.
- W3000365840 hasPrimaryLocation W30003658401 @default.
- W3000365840 hasRelatedWork W102419399 @default.
- W3000365840 hasRelatedWork W1518295571 @default.
- W3000365840 hasRelatedWork W1976657964 @default.
- W3000365840 hasRelatedWork W2054523235 @default.
- W3000365840 hasRelatedWork W2347932394 @default.
- W3000365840 hasRelatedWork W2351093586 @default.
- W3000365840 hasRelatedWork W2373897826 @default.
- W3000365840 hasRelatedWork W2390511743 @default.
- W3000365840 hasRelatedWork W2972647879 @default.
- W3000365840 hasRelatedWork W4283171337 @default.
- W3000365840 isParatext "false" @default.
- W3000365840 isRetracted "false" @default.
- W3000365840 magId "3000365840" @default.
- W3000365840 workType "article" @default.