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• W3000388321 abstract "Summary Background Matrix metalloproteinases (MMPs) are involved in systemic inflammatory responses and organ failure. The aim of this study was to evaluate early circulating plasma levels of MMP‑2, MMP‑9 and their inhibitors TIMP‑1 and TIMP‑2 and their prognostic significance in critically ill patients on admission to the intensive care unit (ICU). Methods In a single center prospective study 120 consecutive patients (72.5% male, mean age 66.8 ± 13.3 years, mean simplified acute physiology score [SAPS II] score 52.9 ± 21.9) were enrolled on transfer to the ICU of a cardiology department. The most common underlying conditions were cardiac diseases ( n = 42.5%), respiratory failure ( n = 10.8%) and sepsis ( n = 6.7%). Blood samples were taken within 12 h of ICU admission. The MMP‑2, MMP‑9, TIMP‑1 and TIMP‑2 levels in plasma were evaluated in terms of 30-day survival, underlying condition and clinical score. Results On ICU admission 30-day survivors had significantly lower plasma MMP‑9 (odds ratio, OR 1.67 per 1 SD; 95% confidence interval, CI 1.10−2.53; p = 0.016) and TIMP‑1 (OR 2.15 per 1 SD; 95% CI 1.27−3.64; p = 0.004) levels than non-survivors; furthermore, MMP‑9 and TIMP‑1 correlated well with SAPS II (both p < 0.01). In patients with underlying cardiac diseases, MMP‑9 ( p = 0.002) and TIMP‑1 ( p = 0.01) were independent predictors of survival (Cox regression). No significant correlation was found between MMP‑2 and TIMP‑2 levels, MMP/TIMP ratios and 30-day mortality. Conclusion The MMP‑9 and TIMP‑1 levels are significantly elevated in acute critical care settings with increased short-term mortality risk, especially in patients with underlying heart disease. These findings support the value of MMPs and TIMPs as prognostic markers and potential therapeutic targets in conditions leading to systemic inflammation and acute organ failure." @default.
• W3000388321 created "2020-01-23" @default.
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• W3000388321 date "2020-01-13" @default.
• W3000388321 modified "2023-10-18" @default.
• W3000388321 title "Plasma MMP-9 and TIMP-1 levels on ICU admission are associated with 30-day survival" @default.
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• W3000388321 cites W1754445010 @default.
• W3000388321 cites W1933241387 @default.
• W3000388321 cites W1964007959 @default.
• W3000388321 cites W1972318201 @default.
• W3000388321 cites W1976240497 @default.
• W3000388321 cites W1980740801 @default.
• W3000388321 cites W1987034289 @default.
• W3000388321 cites W1987825791 @default.
• W3000388321 cites W1988769907 @default.
• W3000388321 cites W2000974608 @default.
• W3000388321 cites W2010004352 @default.
• W3000388321 cites W2012957301 @default.
• W3000388321 cites W2025149824 @default.
• W3000388321 cites W2027415934 @default.
• W3000388321 cites W2033042169 @default.
• W3000388321 cites W2036481082 @default.
• W3000388321 cites W2047853476 @default.
• W3000388321 cites W2054234083 @default.
• W3000388321 cites W2062784484 @default.
• W3000388321 cites W2074059782 @default.
• W3000388321 cites W2077187989 @default.
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• W3000388321 cites W2094666810 @default.
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• W3000388321 cites W2106834148 @default.
• W3000388321 cites W2132121238 @default.
• W3000388321 cites W2135423586 @default.
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• W3000388321 cites W2139905382 @default.
• W3000388321 cites W2140655858 @default.
• W3000388321 cites W2147005862 @default.
• W3000388321 cites W2148075660 @default.
• W3000388321 cites W2149376322 @default.
• W3000388321 cites W2165112249 @default.
• W3000388321 cites W2166902104 @default.
• W3000388321 cites W2168649322 @default.
• W3000388321 cites W2198646327 @default.
• W3000388321 cites W2209395962 @default.
• W3000388321 cites W2332656577 @default.
• W3000388321 cites W2358286550 @default.
• W3000388321 cites W2490219786 @default.
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• W3000388321 cites W2596947530 @default.
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• W3000388321 cites W2931319194 @default.
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• W3000388321 doi "https://doi.org/10.1007/s00508-019-01592-x" @default.
• W3000388321 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7875947" @default.
• W3000388321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31932967" @default.
• W3000388321 hasPublicationYear "2020" @default.
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