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- W3000410320 abstract "Abstract Several pathogens continuously threaten viticulture worldwide. Until now, the investigation on resistance loci has been the main trend to understand the interaction between grapevine and mildew causal agents. Dominantly inherited gene-based resistance has shown to be race-specific in some cases, to confer partial immunity and to be potentially overcome within a few years since its introgression. Recently, on the footprint of research conducted on Arabidopsis, the putative hortologues of genes associated with downy mildew susceptibility in this species, have been discovered also in the grapevine genome. In this work, we deep-resequenced four putative susceptibility genes in 190 highly genetically diverse grapevine genotypes to discover new sources of broad-spectrum recessively inherited resistance. The scouted genes are VvDMR6-1, VvDMR6-2, VvDLO1, VvDLO2 and predicted to be involved in susceptibility to downy mildew. From all identified mutations, 56% were Single Nucleotide Polymorphisms (SNPs) in heterozygosity, while the remaining 44% were homozygous. Regarding the identified mutations with putative impact on gene function, we observed ~4% genotypes mutated in VvDMR6-1 and ~8% mutated in VvDMR6-2 , only a handful of genotypes that were mutated in both genes. ~2% and ~7% genotypes showed mutations in VvDLO1 and VvDLO2 respectively, and again a few genotypes resulted mutated in both genes. In particular, 80% of impacting mutations were heterozygous while 20% were homozygous. The current results will inform grapevine genetics and corroborate genomic-assisted breeding programs for resistance to biotic stresses. Significance statement A survey on the genetic diversity of downy mildew susceptibility genes in grapevine varieties and wild species reveals a potential valuable for genomic-assisted breeding as well as tailored gene editing to induce disease resistance." @default.
- W3000410320 created "2020-01-23" @default.
- W3000410320 creator A5035748127 @default.
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- W3000410320 creator A5041362592 @default.
- W3000410320 creator A5049844920 @default.
- W3000410320 creator A5059565731 @default.
- W3000410320 date "2020-01-15" @default.
- W3000410320 modified "2023-09-27" @default.
- W3000410320 title "Mining downy mildew susceptibility genes: a diversity study in grapevine" @default.
- W3000410320 cites W1122333632 @default.
- W3000410320 cites W1480715709 @default.
- W3000410320 cites W1494075612 @default.
- W3000410320 cites W1560486229 @default.
- W3000410320 cites W1879738161 @default.
- W3000410320 cites W1885613479 @default.
- W3000410320 cites W190954123 @default.
- W3000410320 cites W1950949146 @default.
- W3000410320 cites W1967448179 @default.
- W3000410320 cites W1970989732 @default.
- W3000410320 cites W1973652210 @default.
- W3000410320 cites W1973719475 @default.
- W3000410320 cites W1980740976 @default.
- W3000410320 cites W1994145712 @default.
- W3000410320 cites W1998634450 @default.
- W3000410320 cites W2003291503 @default.
- W3000410320 cites W2011460602 @default.
- W3000410320 cites W2019052783 @default.
- W3000410320 cites W2021479968 @default.
- W3000410320 cites W2037177049 @default.
- W3000410320 cites W2051311491 @default.
- W3000410320 cites W2055987794 @default.
- W3000410320 cites W2059847533 @default.
- W3000410320 cites W2062795065 @default.
- W3000410320 cites W2081046556 @default.
- W3000410320 cites W2084123518 @default.
- W3000410320 cites W2092674131 @default.
- W3000410320 cites W2093779882 @default.
- W3000410320 cites W2095054278 @default.
- W3000410320 cites W2097906839 @default.
- W3000410320 cites W2106007318 @default.
- W3000410320 cites W2106578986 @default.
- W3000410320 cites W2108234281 @default.
- W3000410320 cites W2112613288 @default.
- W3000410320 cites W2115483901 @default.
- W3000410320 cites W2120840252 @default.
- W3000410320 cites W2122622730 @default.
- W3000410320 cites W2125035722 @default.
- W3000410320 cites W2125346198 @default.
- W3000410320 cites W2128113924 @default.
- W3000410320 cites W2132855915 @default.
- W3000410320 cites W2133967392 @default.
- W3000410320 cites W2134800079 @default.
- W3000410320 cites W2137797806 @default.
- W3000410320 cites W2145199245 @default.
- W3000410320 cites W2147818769 @default.
- W3000410320 cites W2149992227 @default.
- W3000410320 cites W2150148265 @default.
- W3000410320 cites W2150457970 @default.
- W3000410320 cites W2154890152 @default.
- W3000410320 cites W2162515800 @default.
- W3000410320 cites W2165405863 @default.
- W3000410320 cites W2167164537 @default.
- W3000410320 cites W2171661952 @default.
- W3000410320 cites W2185163182 @default.
- W3000410320 cites W2291249508 @default.
- W3000410320 cites W2336330324 @default.
- W3000410320 cites W2341537406 @default.
- W3000410320 cites W2395107276 @default.
- W3000410320 cites W2460532444 @default.
- W3000410320 cites W2502411918 @default.
- W3000410320 cites W2551165529 @default.
- W3000410320 cites W2572103236 @default.
- W3000410320 cites W2594424275 @default.
- W3000410320 cites W2598716280 @default.
- W3000410320 cites W2617440950 @default.
- W3000410320 cites W2622731166 @default.
- W3000410320 cites W2747382786 @default.
- W3000410320 cites W2754920951 @default.
- W3000410320 cites W2756471683 @default.
- W3000410320 cites W2772233928 @default.
- W3000410320 cites W2801925923 @default.
- W3000410320 cites W2801983997 @default.
- W3000410320 cites W2884151172 @default.
- W3000410320 cites W2903250268 @default.
- W3000410320 cites W2905999012 @default.
- W3000410320 cites W2908215394 @default.
- W3000410320 cites W2912652602 @default.
- W3000410320 cites W2912807592 @default.
- W3000410320 cites W2913278649 @default.
- W3000410320 cites W2915823955 @default.
- W3000410320 cites W2943867243 @default.
- W3000410320 cites W2952161317 @default.
- W3000410320 cites W2966334212 @default.
- W3000410320 cites W2966550313 @default.
- W3000410320 cites W2967721347 @default.
- W3000410320 cites W4206694472 @default.
- W3000410320 cites W4234682448 @default.
- W3000410320 cites W4247053599 @default.