Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000425121> ?p ?o ?g. }
- W3000425121 endingPage "504" @default.
- W3000425121 startingPage "497" @default.
- W3000425121 abstract "Abstract The 3‐DAA regimen consisting of ombitasvir/paritaprevir/ritonavir plus dasabuvir (OBV/PTV/r + DSV) ± ribavirin (RBV) has shown high sustained virologic response rates (~95%) in phase 3 clinical trials including >2300 HCV genotype 1–infected patients. Real‐world evidence studies have confirmed the effectiveness of OBV/PTV/r ± DSV ± RBV in patients with chronic HCV genotype 1 infection and are consistent with clinical trial results. TOPAZ‐I and TOPAZ‐II are ongoing phase 3b trials, assessing safety, efficacy and long‐term progression of liver disease and clinical outcomes for up to 5 years post‐treatment in patients treated with OBV/PTV/r + DSV ± RBV. High rates of sustained virologic response (SVR) were achieved regardless of presence or absence of cirrhosis.In this report, we assessed the long‐term progression of liver disease and incidence of clinical outcomes up to 3 years of post‐treatment follow‐up in patients with chronic HCV GT1 infection who were treated with (OBV/PTV/r + DSV) ± RBV in the TOPAZ‐I and TOPAZ‐II studies. Improvements were observed in liver disease markers including FIB‐4, METAVIR and Child‐Pugh scores as well as platelet counts. Clinical outcomes related to long‐term progression of liver disease such as liver decompensation were infrequent (<1%). Hepatocellular carcinoma (HCC) occurred in 1.4% of cirrhotic patients." @default.
- W3000425121 created "2020-01-23" @default.
- W3000425121 creator A5003671579 @default.
- W3000425121 creator A5009598838 @default.
- W3000425121 creator A5021626333 @default.
- W3000425121 creator A5022504737 @default.
- W3000425121 creator A5024836953 @default.
- W3000425121 creator A5027413766 @default.
- W3000425121 creator A5036357185 @default.
- W3000425121 creator A5037078532 @default.
- W3000425121 creator A5037697920 @default.
- W3000425121 creator A5042613443 @default.
- W3000425121 creator A5045769984 @default.
- W3000425121 creator A5052488593 @default.
- W3000425121 creator A5056578595 @default.
- W3000425121 creator A5062914904 @default.
- W3000425121 creator A5066100399 @default.
- W3000425121 date "2020-02-17" @default.
- W3000425121 modified "2023-10-04" @default.
- W3000425121 title "Long‐term safety and efficacy results in hepatitis C virus genotype 1‒infected patients receiving ombitasvir/paritaprevir/ritonavir + dasabuvir ± ribavirin in the TOPAZ‐I and TOPAZ‐II trials" @default.
- W3000425121 cites W1564912886 @default.
- W3000425121 cites W1973675889 @default.
- W3000425121 cites W1983154697 @default.
- W3000425121 cites W2013010588 @default.
- W3000425121 cites W2015172755 @default.
- W3000425121 cites W2043193067 @default.
- W3000425121 cites W2046309921 @default.
- W3000425121 cites W2051027258 @default.
- W3000425121 cites W2052313548 @default.
- W3000425121 cites W2058128629 @default.
- W3000425121 cites W2062395204 @default.
- W3000425121 cites W2067273401 @default.
- W3000425121 cites W2069336904 @default.
- W3000425121 cites W2070310839 @default.
- W3000425121 cites W2079462324 @default.
- W3000425121 cites W2090439540 @default.
- W3000425121 cites W2097388257 @default.
- W3000425121 cites W2113428683 @default.
- W3000425121 cites W2114985397 @default.
- W3000425121 cites W2128100529 @default.
- W3000425121 cites W2403969263 @default.
- W3000425121 cites W2514916723 @default.
- W3000425121 cites W2548207235 @default.
- W3000425121 cites W2734755687 @default.
- W3000425121 cites W2794262809 @default.
- W3000425121 cites W2890778396 @default.
- W3000425121 cites W2913125611 @default.
- W3000425121 cites W4210961054 @default.
- W3000425121 cites W4241616429 @default.
- W3000425121 cites W4254523825 @default.
- W3000425121 doi "https://doi.org/10.1111/jvh.13261" @default.
- W3000425121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31954087" @default.
- W3000425121 hasPublicationYear "2020" @default.
- W3000425121 type Work @default.
- W3000425121 sameAs 3000425121 @default.
- W3000425121 citedByCount "9" @default.
- W3000425121 countsByYear W30004251212020 @default.
- W3000425121 countsByYear W30004251212021 @default.
- W3000425121 countsByYear W30004251212022 @default.
- W3000425121 countsByYear W30004251212023 @default.
- W3000425121 crossrefType "journal-article" @default.
- W3000425121 hasAuthorship W3000425121A5003671579 @default.
- W3000425121 hasAuthorship W3000425121A5009598838 @default.
- W3000425121 hasAuthorship W3000425121A5021626333 @default.
- W3000425121 hasAuthorship W3000425121A5022504737 @default.
- W3000425121 hasAuthorship W3000425121A5024836953 @default.
- W3000425121 hasAuthorship W3000425121A5027413766 @default.
- W3000425121 hasAuthorship W3000425121A5036357185 @default.
- W3000425121 hasAuthorship W3000425121A5037078532 @default.
- W3000425121 hasAuthorship W3000425121A5037697920 @default.
- W3000425121 hasAuthorship W3000425121A5042613443 @default.
- W3000425121 hasAuthorship W3000425121A5045769984 @default.
- W3000425121 hasAuthorship W3000425121A5052488593 @default.
- W3000425121 hasAuthorship W3000425121A5056578595 @default.
- W3000425121 hasAuthorship W3000425121A5062914904 @default.
- W3000425121 hasAuthorship W3000425121A5066100399 @default.
- W3000425121 hasConcept C126322002 @default.
- W3000425121 hasConcept C142462285 @default.
- W3000425121 hasConcept C159047783 @default.
- W3000425121 hasConcept C2522874641 @default.
- W3000425121 hasConcept C2776408679 @default.
- W3000425121 hasConcept C2777100407 @default.
- W3000425121 hasConcept C2778785139 @default.
- W3000425121 hasConcept C2778867932 @default.
- W3000425121 hasConcept C2779298103 @default.
- W3000425121 hasConcept C2780040827 @default.
- W3000425121 hasConcept C2993143319 @default.
- W3000425121 hasConcept C71924100 @default.
- W3000425121 hasConcept C90924648 @default.
- W3000425121 hasConceptScore W3000425121C126322002 @default.
- W3000425121 hasConceptScore W3000425121C142462285 @default.
- W3000425121 hasConceptScore W3000425121C159047783 @default.
- W3000425121 hasConceptScore W3000425121C2522874641 @default.
- W3000425121 hasConceptScore W3000425121C2776408679 @default.
- W3000425121 hasConceptScore W3000425121C2777100407 @default.
- W3000425121 hasConceptScore W3000425121C2778785139 @default.
- W3000425121 hasConceptScore W3000425121C2778867932 @default.
- W3000425121 hasConceptScore W3000425121C2779298103 @default.