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• W3000432993 abstract "Abstract Injury of endothelium is an inevitable consequence of cardiovascular stent implantation, which increases the incidence of in-stent restenosis (ISR) and late stent thrombosis (LST). Rapid and complete re-endothelialization, along with long-term suppression of smooth muscle cells (SMCs) are mandatory to alleviate these complications. To this goal, we designed a multi-functional stent coating, consisting of a vascular endothelial growth factor/CuII-dopamine(VEGF/CuII-DA) complex network for a spatiotemporal delivery of VEGF and nitric oxide (NO). We fabricated such network using a two-step stent-coating process: first a CuII-DA network with NO catalytic activity via metal-catecholamine coordination chemistry, followed by conjugation of VEGF onto the CuII-DA network via imine formation. The conjugated VEGF significantly accelerated the early-stage endothelial cell (EC) migration/growth for the first 7 days, forming a new and complete endothelial layer on the lumen. Furthermore, Cu ions sustainably decomposed endogenous S-nitrosothiols (RSNOs) in the bloodstream into NO for over 30 days, suppressing SMC migration/proliferation and ultimately preventing ISR and LST. Altogether, such designed stent coating provides options for a phase-adjusted endothelial repair during cardiovascular treatment." @default.
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• W3000432993 date "2020-06-01" @default.
• W3000432993 modified "2023-09-27" @default.
• W3000432993 title "Spatiotemporal dual-delivery of therapeutic gas and growth factor for prevention of vascular stent thrombosis and restenosis" @default.
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• W3000432993 doi "https://doi.org/10.1016/j.apmt.2019.100546" @default.
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