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- W3000438712 abstract "Enhancers are cis-acting elements with many sites bound by transcription factors and activate transcription over long distance. Histone modifications are critical for enhancer activity and utilized as hallmarks for the identification of putative enhancers. Monomethylation of histone H3 lysine 4 (H3K4me1) is the mark for enhancer priming; acetylation of histone H3 lysine 27 (H3K27ac) for active enhancers and trimethylation of histone H3 lysine 27 (H3K27me3) for silent enhancers. Recent studies from multiple groups have provided evidence that enhancer reprogramming, especially gain of enhancer activity, is closely related to tumorigenesis and cancer development. In this review, we will summarize the recent discoveries about enhancer regulation and the mechanisms of enhancer reprogramming in tumorigenesis, and discuss the potential application of enhancer manipulation in precision medicine." @default.
- W3000438712 created "2020-01-23" @default.
- W3000438712 creator A5022557126 @default.
- W3000438712 creator A5042006304 @default.
- W3000438712 creator A5044766614 @default.
- W3000438712 creator A5079169646 @default.
- W3000438712 date "2020-01-01" @default.
- W3000438712 modified "2023-10-13" @default.
- W3000438712 title "Epigenetic plasticity of enhancers in cancer" @default.
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