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Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000471804> ?p ?o ?g. }

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• W3000471804 abstract "Abstract Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening hyperinflammatory syndrome triggered by EBV infection. It often becomes relapsed or refractory (r/r), given that etoposide-based regimens cannot effectively clear the virus. r/r EBV-HLH is invariably lethal in adults without allogeneic hematopoietic stem cell transplantation. Here, we performed a retrospective analysis of 7 r/r EBV-HLH patients who were treated with nivolumab on a compassionate-use basis at West China Hospital. All 7 patients tolerated the treatment and 6 responded to it. Five of them achieved and remained in clinical complete remission with a median follow-up of 16 months (range, 11.4-18.9 months). Importantly, both plasma and cellular EBV-DNAs were completely eradicated in 4 patients. Single-cell RNA-sequencing analysis showed that HLH syndrome was associated with hyperactive monocytes/macrophages and ineffective CD8 T cells with a defective activation program. Nivolumab treatment expanded programmed death protein-1–positive T cells and restored the expression of HLH-associated degranulation and costimulatory genes in CD8 T cells. Our data suggest that nivolumab, as a monotherapy, provides a potential cure for r/r EBV-HLH, most likely by restoring a defective anti-EBV response." @default.
• W3000471804 created "2020-01-23" @default.
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• W3000471804 date "2020-03-12" @default.
• W3000471804 modified "2023-10-12" @default.
• W3000471804 title "Nivolumab treatment of relapsed/refractory Epstein-Barr virus–associated hemophagocytic lymphohistiocytosis in adults" @default.
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• W3000471804 doi "https://doi.org/10.1182/blood.2019003886" @default.
• W3000471804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31914172" @default.
• W3000471804 hasPublicationYear "2020" @default.
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