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• W3000493005 abstract "ABSTRACT In this study we analyze the growth-phase dependent metabolic states of Bdellovibrio bacteriovorus by constructing a fully compartmented, mass and charge-balanced genome-scale metabolic model of this predatory bacterium ( i CH457). Considering the differences between life cycle phases driving the growth of this predator, growth-phase condition-specific models have been generated allowing the systematic study of its metabolic capabilities. Using these unprecedented computational tools, we have been able to analyze, from a system level, the dynamic metabolism of the predatory bacteria as the life cycle progresses. We provide solid computational evidences supporting potential axenic growth of B. bacteriovorus ’s in a rich medium based its encoded metabolic capabilities. Our systems-level analysis confirms the presence of “energy-saving” mechanisms in this predator as well as an abrupt metabolic shift between the attack and intraperiplasmic growth phases. Our results strongly suggest that predatory bacteria’s metabolic networks have low robustness, likely hampering their ability to tackle drastic environmental fluctuations, thus being confined to stable and predictable habitats. Overall, we present here a valuable computational testbed based on predatory bacteria activity for rational design of novel and controlled biocatalysts in biotechnological/clinical applications. AUTHOR SUMMARY Bacterial predation is an interspecific relationship widely extended in nature. Among other predators, Bdellovibrio and like organism (BALOs) have received recently a great attention due to the high potential applications such as biocontrol agent in medicine, agriculture, aquaculture and water treatment. Despite the increasing interest in of this predatory bacterium its complex lifestyle and growth conditions hamper the full exploitation of their biotechnological properties. In order to overcome these important shortcomings, we provide here the first genome-scale model of a predator bacterium constructed so far. By using the model as a computational testbed, we provide solid evidences of the metabolic autonomy of this interesting bacterium in term of growth, as well as its dynamic metabolism powering the biphasic life style of this predator. We found a low metabolic robustness thus suggesting that Bdellovibrio is more niche-specific than previously thought and that the environmental conditions governing predation may be relatively uniform. Overall, we provide here a valuable computational tool largely facilitating rational design of novel and controlled predator-based biocatalysts in biotechnological/clinical applications." @default.
• W3000493005 created "2020-01-23" @default.
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• W3000493005 date "2020-01-13" @default.
• W3000493005 modified "2023-10-14" @default.
• W3000493005 title "Providing new insights on the byphasic lifestyle of the predatory bacterium Bdellovibrio bacteriovorus through genome-scale metabolic modeling" @default.
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• W3000493005 doi "https://doi.org/10.1101/2020.01.13.904078" @default.
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