FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000497625> ?p ?o ?g. }

• W3000497625 endingPage "900" @default.
• W3000497625 startingPage "889" @default.
• W3000497625 abstract "FLT3 (FMS-like tyrosine kinase 3), expressed on the surface of acute myeloid leukemia (AML) blasts, is a promising AML target, given its role in the development and progression of leukemia, and its limited expression in tissues outside the hematopoietic system. Small molecule FLT3 kinase inhibitors have been developed, but despite having clinical efficacy, they are effective only on a subset of patients and associated with high risk of relapse. A durable therapy that can target a wider population of AML patients is needed. Here, we developed an anti-FLT3-CD3 immunoglobulin G (IgG)-based bispecific antibody (7370) with a high affinity for FLT3 and a long half-life, to target FLT3-expressing AML blasts, irrespective of FLT3 mutational status. We demonstrated that 7370 has picomolar potency against AML cell lines in vitro and in vivo. 7370 was also capable of activating T cells from AML patients, redirecting their cytotoxic activity against autologous blasts at low effector-to-target (E:T) ratio. Additionally, under our dosing regimen, 7370 was well tolerated and exhibited potent efficacy in cynomolgus monkeys by inducing complete but reversible depletion of peripheral FLT3+ dendritic cells (DCs) and bone marrow FLT3+ stem cells and progenitors. Overall, our results support further clinical development of 7370 to broadly target AML patients." @default.
• W3000497625 created "2020-01-23" @default.
• W3000497625 creator A5004214618 @default.
• W3000497625 creator A5005556954 @default.
• W3000497625 creator A5005770383 @default.
• W3000497625 creator A5006463781 @default.
• W3000497625 creator A5015404967 @default.
• W3000497625 creator A5016948773 @default.
• W3000497625 creator A5021940666 @default.
• W3000497625 creator A5029423589 @default.
• W3000497625 creator A5038447904 @default.
• W3000497625 creator A5039496277 @default.
• W3000497625 creator A5042641999 @default.
• W3000497625 creator A5045876748 @default.
• W3000497625 creator A5052782451 @default.
• W3000497625 creator A5056289171 @default.
• W3000497625 creator A5063972747 @default.
• W3000497625 creator A5071640273 @default.
• W3000497625 date "2020-03-01" @default.
• W3000497625 modified "2023-10-13" @default.
• W3000497625 title "An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity" @default.
• W3000497625 cites W1255676896 @default.
• W3000497625 cites W1483299903 @default.
• W3000497625 cites W1506423591 @default.
• W3000497625 cites W1860660725 @default.
• W3000497625 cites W1906337113 @default.
• W3000497625 cites W1971028883 @default.
• W3000497625 cites W1991644988 @default.
• W3000497625 cites W2000056109 @default.
• W3000497625 cites W2000686840 @default.
• W3000497625 cites W2014275356 @default.
• W3000497625 cites W2015956932 @default.
• W3000497625 cites W2019789998 @default.
• W3000497625 cites W2030621571 @default.
• W3000497625 cites W2034087529 @default.
• W3000497625 cites W2055342376 @default.
• W3000497625 cites W2056465113 @default.
• W3000497625 cites W2067656626 @default.
• W3000497625 cites W2076560655 @default.
• W3000497625 cites W2076601151 @default.
• W3000497625 cites W2088071763 @default.
• W3000497625 cites W2089460727 @default.
• W3000497625 cites W2096420946 @default.
• W3000497625 cites W2112641034 @default.
• W3000497625 cites W2123158501 @default.
• W3000497625 cites W2150470057 @default.
• W3000497625 cites W2151222524 @default.
• W3000497625 cites W2151918137 @default.
• W3000497625 cites W2165392081 @default.
• W3000497625 cites W2210801850 @default.
• W3000497625 cites W2259451566 @default.
• W3000497625 cites W2280729002 @default.
• W3000497625 cites W2400030613 @default.
• W3000497625 cites W2506616866 @default.
• W3000497625 cites W2530614832 @default.
• W3000497625 cites W2549154422 @default.
• W3000497625 cites W2558279374 @default.
• W3000497625 cites W2592173429 @default.
• W3000497625 cites W2600672372 @default.
• W3000497625 cites W2613026858 @default.
• W3000497625 cites W2620653306 @default.
• W3000497625 cites W2755246428 @default.
• W3000497625 cites W2767440408 @default.
• W3000497625 cites W2791898577 @default.
• W3000497625 cites W2797410539 @default.
• W3000497625 cites W2804727484 @default.
• W3000497625 cites W2806102119 @default.
• W3000497625 cites W2907903963 @default.
• W3000497625 cites W4231346141 @default.
• W3000497625 doi "https://doi.org/10.1016/j.ymthe.2019.12.014" @default.
• W3000497625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054815" @default.
• W3000497625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31981494" @default.
• W3000497625 hasPublicationYear "2020" @default.
• W3000497625 type Work @default.
• W3000497625 sameAs 3000497625 @default.
• W3000497625 citedByCount "24" @default.
• W3000497625 countsByYear W30004976252020 @default.
• W3000497625 countsByYear W30004976252021 @default.
• W3000497625 countsByYear W30004976252022 @default.
• W3000497625 countsByYear W30004976252023 @default.
• W3000497625 crossrefType "journal-article" @default.
• W3000497625 hasAuthorship W3000497625A5004214618 @default.
• W3000497625 hasAuthorship W3000497625A5005556954 @default.
• W3000497625 hasAuthorship W3000497625A5005770383 @default.
• W3000497625 hasAuthorship W3000497625A5006463781 @default.
• W3000497625 hasAuthorship W3000497625A5015404967 @default.
• W3000497625 hasAuthorship W3000497625A5016948773 @default.
• W3000497625 hasAuthorship W3000497625A5021940666 @default.
• W3000497625 hasAuthorship W3000497625A5029423589 @default.
• W3000497625 hasAuthorship W3000497625A5038447904 @default.
• W3000497625 hasAuthorship W3000497625A5039496277 @default.
• W3000497625 hasAuthorship W3000497625A5042641999 @default.
• W3000497625 hasAuthorship W3000497625A5045876748 @default.
• W3000497625 hasAuthorship W3000497625A5052782451 @default.
• W3000497625 hasAuthorship W3000497625A5056289171 @default.
• W3000497625 hasAuthorship W3000497625A5063972747 @default.
• W3000497625 hasAuthorship W3000497625A5071640273 @default.
• W3000497625 hasBestOaLocation W30004976251 @default.

• next