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• W3000516537 abstract "In times of emerging multi-drug resistance among Gram-negative bacteria (including Salmonella enterica, Serovar Typhi), we observed relapse of typhoid fever following delayed response to treatment with meropenem, suggestive for limited clinical efficacy of the drug. Three previously published cases supported our suspicion. Within this context, we discuss the case details with a focus on potential explanations for insufficient clinical response to meropenem (e.g. limited intracellular penetration, phenomena of tolerance and persistence). Meropenem is a last-resort antimicrobial agent for the treatment of multi-drug resistant Gram-negative infections. Reliable clinical data evaluating the efficacy of meropenem for the treatment of typhoid fever are urgently needed. Future clinical studies evaluating typhoid fever outcome should also investigate the impact of (i) intracellular penetration of antibiotics, and (ii) tolerance and persistence on outcome.In Zeiten zunehmender Multiresistenzen bei Gramnegativen Erregern (Salmonella enterica, Serovar Typhi eingeschlossen) beobachteten wir einen Rückfall nach verzögertem Ansprechen eines Typhus-Patienten auf die Behandlung mit Meropenem. Diese Beobachtung legte den Verdacht nahe, die Wirksamkeit des Antibiotikums könne bei Typhus-Patienten eingeschränkt sein. Drei bereits veröffentlichte Fälle bestätigten diesen Verdacht. Wir diskutieren die Details des Falles, legen den Schwerpunkt der Diskussion aber auf mögliche Erklärungen für ein vermindertes Ansprechen der vier Typhus-Patienten auf Meropenem. Meropenem ist ein Reserve-Antibiotikum zur Behandlung multiresistenter, Gramnegativer Infektionen. Verlässliche Daten zur Wirksamkeit von Meropenem bei Typhus-Patienten werden dringend benötigt. Zukünftige Studien zur Wirksamkeit von Antibiotika zur Behandlung des Typhus sollten auch (i) die Bedeutung des intrazellulären Eindringens der Medikamente und (ii) den Einfluss von Toleranz und Persistenz auf die Wirksamkeit der Therapie untersuchen." @default.
• W3000516537 created "2020-01-23" @default.
• W3000516537 creator A5018017419 @default.
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• W3000516537 creator A5034066540 @default.
• W3000516537 creator A5044211227 @default.
• W3000516537 creator A5088543165 @default.
• W3000516537 date "2019-01-01" @default.
• W3000516537 modified "2023-09-27" @default.
• W3000516537 title "Relapse of typhoid fever following delayed response to meropenem: A case report and review of previously published cases indicating limited clinical efficacy of meropenem for the treatment of typhoid fever." @default.
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• W3000516537 doi "https://doi.org/10.3205/000267" @default.
• W3000516537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6388674" @default.
• W3000516537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30837820" @default.
• W3000516537 hasPublicationYear "2019" @default.
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