FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000535752> ?p ?o ?g. }

• W3000535752 endingPage "136564" @default.
• W3000535752 startingPage "136564" @default.
• W3000535752 abstract "Pharmaceutical compounds are continuously released into the aquatic environment, resulting in their ubiquitous presence in many estuarine and coastal systems. As pharmaceuticals are designed to produce effects at very low concentrations and target specific evolutionary conserved pathways, there are growing concerns over their potential deleterious effects to the environment and specifically to aquatic organisms, namely in early life-stages. In this context, the long-term effects of exposure of juvenile meagre Argyrosomus regius to three different pharmaceuticals were investigated. Fish were exposed to environmental concentrations of one of three major used pharmaceuticals: the antidepressant fluoxetine (0.3 and 3 μg/L for 15 days), the anti-hypertensive propranolol and the non-steroidal anti-inflammatory agent diclofenac (0.3 and 15 μg/L for 30 days). Pharmaceuticals bioconcentration in fish muscle was examined, along with biomarkers in different tissues related with antioxidant and biotransformation responses (catalase, superoxide dismutase, ethoxyresorufin-O-deethylase and glutathione S-transferase), energetic metabolism (lactate dehydrogenase, isocitrate dehydrogenase and electron transport system activities), neurotransmission (acetylcholinesterase activity) and oxidative damage (DNA damage and lipid peroxidation levels). Overall, each pharmaceutical had different potential for bioconcentration in the muscle (FLX > PROP > DCF) and induced different biological responses: fluoxetine was the most toxic compound to juvenile meagre, affecting fish growth, triggering antioxidant defense responses, inhibiting detoxification mechanisms and increasing lipid peroxidation and DNA damage in the liver; propranolol exposure increased DNA damage and decreased aerobic metabolism in fish muscle; and diclofenac showed no potential to bioconcentrate, yet it affected fish metabolism by increasing cellular energy consumption in the muscle and consequently reducing fish net energy budget. The diverse response patterns evidence the need for future research focused on pharmaceuticals with different modes of action and their exposure effects on organismal physiological mechanisms and homeostatic status. Ultimately, the combination of sub-individual and individual responses is key for ecologically relevant assessments of pharmaceutical toxicity." @default.
• W3000535752 created "2020-01-23" @default.
• W3000535752 creator A5004825896 @default.
• W3000535752 creator A5009851316 @default.
• W3000535752 creator A5010933817 @default.
• W3000535752 creator A5028527482 @default.
• W3000535752 creator A5029928006 @default.
• W3000535752 creator A5035455501 @default.
• W3000535752 creator A5042784909 @default.
• W3000535752 creator A5070084344 @default.
• W3000535752 creator A5070358833 @default.
• W3000535752 creator A5091710563 @default.
• W3000535752 date "2020-04-01" @default.
• W3000535752 modified "2023-10-17" @default.
• W3000535752 title "Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish" @default.
• W3000535752 cites W1075120486 @default.
• W3000535752 cites W1581414347 @default.
• W3000535752 cites W1964522544 @default.
• W3000535752 cites W1966325974 @default.
• W3000535752 cites W1967304129 @default.
• W3000535752 cites W1969445695 @default.
• W3000535752 cites W1969906981 @default.
• W3000535752 cites W1971048984 @default.
• W3000535752 cites W1971387833 @default.
• W3000535752 cites W1974036244 @default.
• W3000535752 cites W1974210914 @default.
• W3000535752 cites W1980449509 @default.
• W3000535752 cites W1983310681 @default.
• W3000535752 cites W1989488807 @default.
• W3000535752 cites W1993113048 @default.
• W3000535752 cites W1993413711 @default.
• W3000535752 cites W1999074746 @default.
• W3000535752 cites W2007692081 @default.
• W3000535752 cites W2018497432 @default.
• W3000535752 cites W2026765020 @default.
• W3000535752 cites W2033859315 @default.
• W3000535752 cites W2035079397 @default.
• W3000535752 cites W2036582121 @default.
• W3000535752 cites W2037462979 @default.
• W3000535752 cites W2040919827 @default.
• W3000535752 cites W2041283704 @default.
• W3000535752 cites W2041698712 @default.
• W3000535752 cites W2050511211 @default.
• W3000535752 cites W2057536271 @default.
• W3000535752 cites W2058589044 @default.
• W3000535752 cites W2060611935 @default.
• W3000535752 cites W2066645412 @default.
• W3000535752 cites W2074441044 @default.
• W3000535752 cites W2075819625 @default.
• W3000535752 cites W2076216973 @default.
• W3000535752 cites W2076288335 @default.
• W3000535752 cites W2076442468 @default.
• W3000535752 cites W2078413678 @default.
• W3000535752 cites W2127786285 @default.
• W3000535752 cites W2131960328 @default.
• W3000535752 cites W2135488502 @default.
• W3000535752 cites W2137340670 @default.
• W3000535752 cites W2139233728 @default.
• W3000535752 cites W2142760072 @default.
• W3000535752 cites W2145937475 @default.
• W3000535752 cites W2148568928 @default.
• W3000535752 cites W2151552545 @default.
• W3000535752 cites W2159756892 @default.
• W3000535752 cites W2162534278 @default.
• W3000535752 cites W2175581444 @default.
• W3000535752 cites W226124516 @default.
• W3000535752 cites W2266189662 @default.
• W3000535752 cites W2297938101 @default.
• W3000535752 cites W2341834780 @default.
• W3000535752 cites W2571323631 @default.
• W3000535752 cites W2587657690 @default.
• W3000535752 cites W2588075332 @default.
• W3000535752 cites W2592554886 @default.
• W3000535752 cites W2606824530 @default.
• W3000535752 cites W2741574277 @default.
• W3000535752 cites W2752940220 @default.
• W3000535752 cites W2790047015 @default.
• W3000535752 cites W2794324076 @default.
• W3000535752 cites W2799895924 @default.
• W3000535752 cites W2800899785 @default.
• W3000535752 cites W2803803228 @default.
• W3000535752 cites W2803897237 @default.
• W3000535752 cites W2809967408 @default.
• W3000535752 cites W2888392044 @default.
• W3000535752 cites W2898262737 @default.
• W3000535752 cites W2913006768 @default.
• W3000535752 cites W2934167092 @default.
• W3000535752 cites W2948922151 @default.
• W3000535752 cites W642287933 @default.
• W3000535752 doi "https://doi.org/10.1016/j.scitotenv.2020.136564" @default.
• W3000535752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31945523" @default.
• W3000535752 hasPublicationYear "2020" @default.
• W3000535752 type Work @default.
• W3000535752 sameAs 3000535752 @default.
• W3000535752 citedByCount "47" @default.
• W3000535752 countsByYear W30005357522020 @default.
• W3000535752 countsByYear W30005357522021 @default.
• W3000535752 countsByYear W30005357522022 @default.

• next