FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000537286> ?p ?o ?g. }

• W3000537286 endingPage "E623" @default.
• W3000537286 startingPage "E616" @default.
• W3000537286 abstract "Study Design. Meta-analysis to collect relevant studies to assess the association between COL11A1 and GDF5 genetic variants and susceptibility to IDD. Objective. The aim of this study was to assess whether or not COL11A1 and GDF5 genetic variants were associated with susceptibility to IDD. Summary of Background Data. IDD or LDH is a major public health problem. There have been several studies evaluating the relationship between COL11A1 and GDF5 genetic variants with risk of intervertebral disc degeneration (IDD). However, the studies were limited in discrete outcome and sample size, and some of the results were contradictory. Methods. We systematically searched the relevant publications in electronic databases. Eligible studies were included based on the defined criteria. The pooled odds ratios (ORs) with its 95% confidence intervals (CIs) were received using STATA 15. Subgroup analysis, sensitivity analysis, publication bias, and the “Trim and fill” method were performed in the meta-analysis. Results. A total of 3287 IDD cases and 5115 controls were incorporated into the meta-analysis. Our results demonstrated that COL11A1 rs1676486 was significantly associated with increased IDD susceptibility under all genetic models (allele model T vs. C: OR = 1.40, 95% CI 1.23–1.59, P = 0.000; homozygote model TT vs. CC: OR = 1.89, 95%CI 1.40–2.56, P = 0.000; dominant model TT+TC vs. CC: OR = 1.52, 95% CI 1.29–1.80, P = 0.000; recessive model TT vs. TC + CC: OR = 1.58, 95% CI 1.18–2.12, P = 0.002). However, GDF5 rs143383 was not (allele model T vs. C: OR = 1.15, 95% CI 0.91–1.44, P = 0.244; homozygote model TT vs. CC: OR = 1.22, 95% CI 0.75–2.00, P = 0.429; dominant model TT vs. CC+CT: OR = 1.22, 95% CI 0.95–1.57, P = 0.112; recessive model TC + TT vs. CC: OR = 1.12, 95% CI 0.73–1.73, P = 0.594). Subgroup analysis indicated ethnicity was not the source of heterogeneity. Sensitivity analysis, publication bias, and the “Trim and fill” method demonstrated the meta-analysis was of reliability. Conclusion. Our results suggested that COL11A1 rs1676486 was significantly associated with IDD and the T allele was a risky factor. However, GDF5 rs143383 was not. Level of Evidence: 1" @default.
• W3000537286 created "2020-01-23" @default.
• W3000537286 creator A5018406495 @default.
• W3000537286 creator A5071111968 @default.
• W3000537286 creator A5077610728 @default.
• W3000537286 creator A5086114121 @default.
• W3000537286 date "2020-01-09" @default.
• W3000537286 modified "2023-10-17" @default.
• W3000537286 title "A Meta-analysis Assessing the Association Between COL11A1 and GDF5 Genetic Variants and Intervertebral Disc Degeneration Susceptibility" @default.
• W3000537286 cites W1494494434 @default.
• W3000537286 cites W1969933373 @default.
• W3000537286 cites W1972583757 @default.
• W3000537286 cites W1982891441 @default.
• W3000537286 cites W1984757452 @default.
• W3000537286 cites W1994773119 @default.
• W3000537286 cites W1996917356 @default.
• W3000537286 cites W2003352875 @default.
• W3000537286 cites W2021374356 @default.
• W3000537286 cites W2022044245 @default.
• W3000537286 cites W2025479103 @default.
• W3000537286 cites W2044517274 @default.
• W3000537286 cites W2045115929 @default.
• W3000537286 cites W2046555967 @default.
• W3000537286 cites W2048737732 @default.
• W3000537286 cites W2055377091 @default.
• W3000537286 cites W2056127347 @default.
• W3000537286 cites W2068665095 @default.
• W3000537286 cites W2070759305 @default.
• W3000537286 cites W2104911589 @default.
• W3000537286 cites W2106755981 @default.
• W3000537286 cites W2115523644 @default.
• W3000537286 cites W2117983806 @default.
• W3000537286 cites W2126147204 @default.
• W3000537286 cites W2128431867 @default.
• W3000537286 cites W2157823046 @default.
• W3000537286 cites W2159009641 @default.
• W3000537286 cites W2169867126 @default.
• W3000537286 cites W2589716687 @default.
• W3000537286 cites W2623269111 @default.
• W3000537286 cites W2773995322 @default.
• W3000537286 cites W2892328403 @default.
• W3000537286 doi "https://doi.org/10.1097/brs.0000000000003371" @default.
• W3000537286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31923126" @default.
• W3000537286 hasPublicationYear "2020" @default.
• W3000537286 type Work @default.
• W3000537286 sameAs 3000537286 @default.
• W3000537286 citedByCount "4" @default.
• W3000537286 countsByYear W30005372862021 @default.
• W3000537286 countsByYear W30005372862023 @default.
• W3000537286 crossrefType "journal-article" @default.
• W3000537286 hasAuthorship W3000537286A5018406495 @default.
• W3000537286 hasAuthorship W3000537286A5071111968 @default.
• W3000537286 hasAuthorship W3000537286A5077610728 @default.
• W3000537286 hasAuthorship W3000537286A5086114121 @default.
• W3000537286 hasConcept C104317684 @default.
• W3000537286 hasConcept C126322002 @default.
• W3000537286 hasConcept C135763542 @default.
• W3000537286 hasConcept C156957248 @default.
• W3000537286 hasConcept C180754005 @default.
• W3000537286 hasConcept C2779134260 @default.
• W3000537286 hasConcept C2780439572 @default.
• W3000537286 hasConcept C2992519594 @default.
• W3000537286 hasConcept C44249647 @default.
• W3000537286 hasConcept C54355233 @default.
• W3000537286 hasConcept C60644358 @default.
• W3000537286 hasConcept C67636389 @default.
• W3000537286 hasConcept C71924100 @default.
• W3000537286 hasConcept C86803240 @default.
• W3000537286 hasConcept C95190672 @default.
• W3000537286 hasConceptScore W3000537286C104317684 @default.
• W3000537286 hasConceptScore W3000537286C126322002 @default.
• W3000537286 hasConceptScore W3000537286C135763542 @default.
• W3000537286 hasConceptScore W3000537286C156957248 @default.
• W3000537286 hasConceptScore W3000537286C180754005 @default.
• W3000537286 hasConceptScore W3000537286C2779134260 @default.
• W3000537286 hasConceptScore W3000537286C2780439572 @default.
• W3000537286 hasConceptScore W3000537286C2992519594 @default.
• W3000537286 hasConceptScore W3000537286C44249647 @default.
• W3000537286 hasConceptScore W3000537286C54355233 @default.
• W3000537286 hasConceptScore W3000537286C60644358 @default.
• W3000537286 hasConceptScore W3000537286C67636389 @default.
• W3000537286 hasConceptScore W3000537286C71924100 @default.
• W3000537286 hasConceptScore W3000537286C86803240 @default.
• W3000537286 hasConceptScore W3000537286C95190672 @default.
• W3000537286 hasIssue "11" @default.
• W3000537286 hasLocation W30005372861 @default.
• W3000537286 hasOpenAccess W3000537286 @default.
• W3000537286 hasPrimaryLocation W30005372861 @default.
• W3000537286 hasRelatedWork W1985716775 @default.
• W3000537286 hasRelatedWork W2159313323 @default.
• W3000537286 hasRelatedWork W2219843541 @default.
• W3000537286 hasRelatedWork W2286371484 @default.
• W3000537286 hasRelatedWork W2302103871 @default.
• W3000537286 hasRelatedWork W2318119155 @default.
• W3000537286 hasRelatedWork W2406708134 @default.
• W3000537286 hasRelatedWork W2808175591 @default.
• W3000537286 hasRelatedWork W2976179431 @default.
• W3000537286 hasRelatedWork W2978727727 @default.

• next