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• W3000543341 abstract "Nicotinamide adenine dinucleotide (NAD) and its phosphorylated form (NADP) are vital for cell function in all organisms and form cofactors to a host of enzymes in catabolic and anabolic processes. NAD(P) transhydrogenases (NTHs) catalyse hydride ion transfer between NAD(H) and NADP(H). Membrane-bound NTH isoforms reside in the cytoplasmic membrane of bacteria, and the inner membrane of mitochondria in metazoans, where they generate NADPH. Here, we show that malaria parasites encode a single membrane-bound NTH that localises to the crystalloid, an organelle required for sporozoite transmission from mosquitos to vertebrates. We demonstrate that NTH has an essential structural role in crystalloid biogenesis, whilst its enzymatic activity is required for sporozoite development. This pinpoints an essential function in sporogony to the activity of a single crystalloid protein. Its additional presence in the apicoplast of sporozoites identifies NTH as a likely supplier of NADPH for this organelle during liver infection. Our findings reveal that Plasmodium species have co-opted NTH to a variety of non-mitochondrial organelles to provide a critical source of NADPH reducing power." @default.
• W3000543341 created "2020-01-23" @default.
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• W3000543341 date "2020-01-17" @default.
• W3000543341 modified "2023-10-13" @default.
• W3000543341 title "<scp>NAD</scp> (P) transhydrogenase has vital non‐mitochondrial functions in malaria parasite transmission" @default.
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• W3000543341 doi "https://doi.org/10.15252/embr.201947832" @default.
• W3000543341 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054674" @default.
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