Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000550260> ?p ?o ?g. }
- W3000550260 endingPage "143" @default.
- W3000550260 startingPage "137" @default.
- W3000550260 abstract "The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma. We evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection by an immunohistochemical analysis. Furthermore, we performed the serial analysis of the PD-L1 status before and after chemotherapy in 15 patients. Among the 31 cases, 11 (35%) showed a positive PD-L1 expression. The survival analysis showed a trend toward an association between PD-L1 positivity and a decreased overall survival. PD-L1 positivity tended to be associated with higher levels of tumor markers. In the serial analysis of the PD-L1 status, positivity was noted in 8 of 15 patients before chemotherapy and 6 after chemotherapy. Notably, all four patients with a positive PD-L1 status both before and after chemotherapy had recurrence, and 3 of them died during the follow-up period. Our findings suggest that the PD-L1 tumor expression might be a good biomarker for the treatment of neuroblastoma patients, especially for advanced neuroblastoma." @default.
- W3000550260 created "2020-01-23" @default.
- W3000550260 creator A5008330817 @default.
- W3000550260 creator A5012620752 @default.
- W3000550260 creator A5016227824 @default.
- W3000550260 creator A5035027513 @default.
- W3000550260 creator A5039525605 @default.
- W3000550260 creator A5040347971 @default.
- W3000550260 creator A5066136586 @default.
- W3000550260 creator A5069330783 @default.
- W3000550260 creator A5084440905 @default.
- W3000550260 date "2020-01-10" @default.
- W3000550260 modified "2023-10-16" @default.
- W3000550260 title "Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma" @default.
- W3000550260 cites W1583533684 @default.
- W3000550260 cites W1755371994 @default.
- W3000550260 cites W1976866237 @default.
- W3000550260 cites W1978161821 @default.
- W3000550260 cites W1982488143 @default.
- W3000550260 cites W1988361291 @default.
- W3000550260 cites W1994238092 @default.
- W3000550260 cites W1994269871 @default.
- W3000550260 cites W2033577259 @default.
- W3000550260 cites W2037313669 @default.
- W3000550260 cites W2060070314 @default.
- W3000550260 cites W2063669319 @default.
- W3000550260 cites W2066671159 @default.
- W3000550260 cites W2095296988 @default.
- W3000550260 cites W2096151993 @default.
- W3000550260 cites W2101653483 @default.
- W3000550260 cites W2109485845 @default.
- W3000550260 cites W2130207101 @default.
- W3000550260 cites W2142300779 @default.
- W3000550260 cites W2147800896 @default.
- W3000550260 cites W2152420890 @default.
- W3000550260 cites W2154697747 @default.
- W3000550260 cites W2156383220 @default.
- W3000550260 cites W2160834915 @default.
- W3000550260 cites W2161558877 @default.
- W3000550260 cites W2284172066 @default.
- W3000550260 cites W2292383635 @default.
- W3000550260 cites W2346121781 @default.
- W3000550260 cites W2491306389 @default.
- W3000550260 cites W2509486054 @default.
- W3000550260 cites W2559382297 @default.
- W3000550260 cites W2560367415 @default.
- W3000550260 cites W2572174216 @default.
- W3000550260 cites W2592211262 @default.
- W3000550260 cites W2622499649 @default.
- W3000550260 cites W2624782256 @default.
- W3000550260 cites W2770700940 @default.
- W3000550260 cites W4230861071 @default.
- W3000550260 cites W4238423864 @default.
- W3000550260 doi "https://doi.org/10.1007/s00383-019-04616-9" @default.
- W3000550260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31925505" @default.
- W3000550260 hasPublicationYear "2020" @default.
- W3000550260 type Work @default.
- W3000550260 sameAs 3000550260 @default.
- W3000550260 citedByCount "14" @default.
- W3000550260 countsByYear W30005502602020 @default.
- W3000550260 countsByYear W30005502602021 @default.
- W3000550260 countsByYear W30005502602022 @default.
- W3000550260 countsByYear W30005502602023 @default.
- W3000550260 crossrefType "journal-article" @default.
- W3000550260 hasAuthorship W3000550260A5008330817 @default.
- W3000550260 hasAuthorship W3000550260A5012620752 @default.
- W3000550260 hasAuthorship W3000550260A5016227824 @default.
- W3000550260 hasAuthorship W3000550260A5035027513 @default.
- W3000550260 hasAuthorship W3000550260A5039525605 @default.
- W3000550260 hasAuthorship W3000550260A5040347971 @default.
- W3000550260 hasAuthorship W3000550260A5066136586 @default.
- W3000550260 hasAuthorship W3000550260A5069330783 @default.
- W3000550260 hasAuthorship W3000550260A5084440905 @default.
- W3000550260 hasBestOaLocation W30005502602 @default.
- W3000550260 hasConcept C121608353 @default.
- W3000550260 hasConcept C126322002 @default.
- W3000550260 hasConcept C142724271 @default.
- W3000550260 hasConcept C143998085 @default.
- W3000550260 hasConcept C204232928 @default.
- W3000550260 hasConcept C2775934546 @default.
- W3000550260 hasConcept C2776694085 @default.
- W3000550260 hasConcept C2776715637 @default.
- W3000550260 hasConcept C2777701055 @default.
- W3000550260 hasConcept C2778326572 @default.
- W3000550260 hasConcept C2781053074 @default.
- W3000550260 hasConcept C54355233 @default.
- W3000550260 hasConcept C71924100 @default.
- W3000550260 hasConcept C81885089 @default.
- W3000550260 hasConcept C86803240 @default.
- W3000550260 hasConceptScore W3000550260C121608353 @default.
- W3000550260 hasConceptScore W3000550260C126322002 @default.
- W3000550260 hasConceptScore W3000550260C142724271 @default.
- W3000550260 hasConceptScore W3000550260C143998085 @default.
- W3000550260 hasConceptScore W3000550260C204232928 @default.
- W3000550260 hasConceptScore W3000550260C2775934546 @default.
- W3000550260 hasConceptScore W3000550260C2776694085 @default.
- W3000550260 hasConceptScore W3000550260C2776715637 @default.
- W3000550260 hasConceptScore W3000550260C2777701055 @default.