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- W3000556457 abstract "Objective. The performance of neuroprostheses, including cochlear and retinal implants, is currently constrained by the spatial resolution of electrical stimulation. Optogenetics has improved the spatial control of neurons in vivo but lacks the fast-temporal dynamics required for auditory and retinal signalling. The objective of this study is to demonstrate that combining optical and electrical stimulation in vitro could address some of the limitations associated with each of the stimulus modes when used independently. Approach. The response of murine auditory neurons expressing ChR2-H134 to combined optical and electrical stimulation was characterised using whole cell patch clamp electrophysiology. Main results. Optogenetic costimulation produces a three-fold increase in peak firing rate compared to optical stimulation alone and allows spikes to be evoked by combined subthreshold optical and electrical inputs. Subthreshold optical depolarisation also facilitated spiking in auditory neurons for periods of up to 30 ms without evidence of wide-scale Na+ inactivation. Significance. These findings may contribute to the development of spatially and temporally selective optogenetic-based neuroprosthetics and complement recent developments in 'fast opsins'." @default.
- W3000556457 created "2020-01-23" @default.
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- W3000556457 date "2020-02-19" @default.
- W3000556457 modified "2023-10-11" @default.
- W3000556457 title "Combined optogenetic and electrical stimulation of auditory neurons increases effective stimulation frequency—an <i>in vitro</i> study" @default.
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- W3000556457 doi "https://doi.org/10.1088/1741-2552/ab6a68" @default.
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