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• W3000568981 endingPage "4805" @default.
• W3000568981 startingPage "4766" @default.
• W3000568981 abstract "The chemistry of abiotic nucleotide synthesis of RNA and DNA in the context of their prebiotic origins on early earth is a continuing challenge. How did (or how can) the nucleotides form and assemble from the small molecule inventories and under conditions that prevailed on early earth 3.5–4 billion years ago? This review provides a background and up-to-date progress that will allow the reader to judge where the field stands currently and what remains to be achieved. We start with a brief primer on the biological synthesis of nucleotides, followed by an extensive focus on the prebiotic formation of the components of nucleotides—either via the synthesis of ribose and the canonical nucleobases and then joining them together or by building both the conjoined sugar and nucleobase, part-by-part—toward the ultimate goal of forming RNA and DNA by polymerization. The review will emphasize that there are—and will continue to be—many more questions than answers from the synthetic, mechanistic, and analytical perspectives. We wrap up the review with a cautionary note in this context about coming to conclusions as to whether the problem of chemistry of prebiotic nucleotide synthesis has been solved." @default.
• W3000568981 created "2020-01-23" @default.
• W3000568981 creator A5018319855 @default.
• W3000568981 creator A5061599852 @default.
• W3000568981 creator A5071333836 @default.
• W3000568981 date "2020-01-09" @default.
• W3000568981 modified "2023-10-14" @default.
• W3000568981 title "Chemistry of Abiotic Nucleotide Synthesis" @default.
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