FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000587707> ?p ?o ?g. }

• W3000587707 endingPage "232" @default.
• W3000587707 startingPage "223" @default.
• W3000587707 abstract "Objective: Anxiety disorders are common and often disabling. The goal of this study was to examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also frequently comorbid with other mental disorders, such as major depressive disorder. Methods: Using one of the world’s largest biobanks including genetic, environmental, and medical information, the Million Veteran Program, the authors performed a genome-wide association study (GWAS) of a continuous trait for anxiety (based on score on the Generalized Anxiety Disorder 2-item scale [GAD-2], N=199,611) as the primary analysis and self-report of physician diagnosis of anxiety disorder (N=224,330) as a secondary analysis. Results: The authors identified five genome-wide significant signals for European Americans and one for African Americans on GAD-2 score. The strongest were on chromosome 3 (rs4603973) near SATB1, a global regulator of gene expression, and on chromosome 6 (rs6557168) near ESR1, which encodes an estrogen receptor. The locus identified on chromosome 7 (rs56226325, MAF=0.17) near MAD1L1 was previously identified in GWASs of bipolar disorder and schizophrenia. The authors replicated these findings in the summary statistics of two major published GWASs for anxiety, and also found evidence of significant genetic correlation between the GAD-2 score results and previous GWASs for anxiety (rg=0.75), depression (rg=0.81), and neuroticism (rg=0.75). Conclusions: This is the largest GWAS of anxiety traits to date. The authors identified novel genome-wide significant associations near genes involved with global regulation of gene expression (SATB1) and the estrogen receptor alpha (ESR1). Additionally, the authors identified a locus (MAD1L1) that may have implications for genetic vulnerability across several psychiatric disorders. This work provides new insights into genetic risk mechanisms underpinning anxiety and related psychiatric disorders." @default.
• W3000587707 created "2020-01-23" @default.
• W3000587707 creator A5001817812 @default.
• W3000587707 creator A5002249552 @default.
• W3000587707 creator A5008982222 @default.
• W3000587707 creator A5020097225 @default.
• W3000587707 creator A5023163958 @default.
• W3000587707 creator A5031117541 @default.
• W3000587707 creator A5043951146 @default.
• W3000587707 creator A5061802355 @default.
• W3000587707 creator A5064459185 @default.
• W3000587707 creator A5066121765 @default.
• W3000587707 creator A5071146655 @default.
• W3000587707 creator A5074969156 @default.
• W3000587707 date "2020-03-01" @default.
• W3000587707 modified "2023-10-11" @default.
• W3000587707 title "Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program" @default.
• W3000587707 cites W1160212399 @default.
• W3000587707 cites W1911952697 @default.
• W3000587707 cites W1968872519 @default.
• W3000587707 cites W1995422036 @default.
• W3000587707 cites W2007965977 @default.
• W3000587707 cites W2007977295 @default.
• W3000587707 cites W2033995133 @default.
• W3000587707 cites W2057468507 @default.
• W3000587707 cites W2058335733 @default.
• W3000587707 cites W2064476502 @default.
• W3000587707 cites W2071742142 @default.
• W3000587707 cites W2078059415 @default.
• W3000587707 cites W2084760480 @default.
• W3000587707 cites W2101357408 @default.
• W3000587707 cites W2101505979 @default.
• W3000587707 cites W2110048796 @default.
• W3000587707 cites W2127761410 @default.
• W3000587707 cites W2132817439 @default.
• W3000587707 cites W2157752701 @default.
• W3000587707 cites W2161633633 @default.
• W3000587707 cites W2162143298 @default.
• W3000587707 cites W2166208178 @default.
• W3000587707 cites W2236290736 @default.
• W3000587707 cites W2267227323 @default.
• W3000587707 cites W2340656051 @default.
• W3000587707 cites W2345621280 @default.
• W3000587707 cites W2405205060 @default.
• W3000587707 cites W2465667391 @default.
• W3000587707 cites W2530092364 @default.
• W3000587707 cites W2593219267 @default.
• W3000587707 cites W2610359325 @default.
• W3000587707 cites W2618323132 @default.
• W3000587707 cites W2626606138 @default.
• W3000587707 cites W2729811681 @default.
• W3000587707 cites W2734609792 @default.
• W3000587707 cites W2738082385 @default.
• W3000587707 cites W2747565683 @default.
• W3000587707 cites W2770092353 @default.
• W3000587707 cites W2803082344 @default.
• W3000587707 cites W2804490018 @default.
• W3000587707 cites W2809666444 @default.
• W3000587707 cites W2911487850 @default.
• W3000587707 cites W2912654919 @default.
• W3000587707 cites W2927029344 @default.
• W3000587707 cites W2933424604 @default.
• W3000587707 cites W2949543964 @default.
• W3000587707 cites W2964961432 @default.
• W3000587707 cites W4210615564 @default.
• W3000587707 cites W4247665917 @default.
• W3000587707 doi "https://doi.org/10.1176/appi.ajp.2019.19030256" @default.
• W3000587707 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7869502" @default.
• W3000587707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31906708" @default.
• W3000587707 hasPublicationYear "2020" @default.
• W3000587707 type Work @default.
• W3000587707 sameAs 3000587707 @default.
• W3000587707 citedByCount "154" @default.
• W3000587707 countsByYear W30005877072019 @default.
• W3000587707 countsByYear W30005877072020 @default.
• W3000587707 countsByYear W30005877072021 @default.
• W3000587707 countsByYear W30005877072022 @default.
• W3000587707 countsByYear W30005877072023 @default.
• W3000587707 crossrefType "journal-article" @default.
• W3000587707 hasAuthorship W3000587707A5001817812 @default.
• W3000587707 hasAuthorship W3000587707A5002249552 @default.
• W3000587707 hasAuthorship W3000587707A5008982222 @default.
• W3000587707 hasAuthorship W3000587707A5020097225 @default.
• W3000587707 hasAuthorship W3000587707A5023163958 @default.
• W3000587707 hasAuthorship W3000587707A5031117541 @default.
• W3000587707 hasAuthorship W3000587707A5043951146 @default.
• W3000587707 hasAuthorship W3000587707A5061802355 @default.
• W3000587707 hasAuthorship W3000587707A5064459185 @default.
• W3000587707 hasAuthorship W3000587707A5066121765 @default.
• W3000587707 hasAuthorship W3000587707A5071146655 @default.
• W3000587707 hasAuthorship W3000587707A5074969156 @default.
• W3000587707 hasBestOaLocation W30005877071 @default.
• W3000587707 hasConcept C104317684 @default.
• W3000587707 hasConcept C106208931 @default.
• W3000587707 hasConcept C118552586 @default.
• W3000587707 hasConcept C135763542 @default.
• W3000587707 hasConcept C153209595 @default.
• W3000587707 hasConcept C15744967 @default.

• next