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• W3000606908 abstract "Although the existence of a cellular heat shock response is nearly universal, its relationship to organismal thermal tolerance is not completely understood. Many of the genes involved are known to be regulated by the highly conserved heat shock transcription factor-1 (HSF-1), yet the regulatory network is not fully characterized. Here we investigate the role of HSF-1 in gene expression following thermal stress using knockdown of HSF-1 by RNA interference (RNAi) in the intertidal copepod Tigriopus californicus. We observed some evidence for decreased transcription of heat shock protein genes following knockdown, supporting the widely acknowledged role of HSF-1 in the heat shock response. However, the majority of differentially expressed genes between the control and HSF-1 knockdown groups were upregulated, suggesting that HSF-1 normally functions to repress their expression. Differential expression observed in genes related to chitin and cuticle formation lends support to previous findings that these processes are highly regulated following heat stress. We performed a genome scan and identified a set of 396 genes associated with canonical heat shock elements. RNA-seq data did not find those genes to be more highly represented in our HSF-1 knockdown treatment, indicating that requirements for binding and interaction of HSF-1 with a given gene are not simply predicted by the presence of HSF-1 binding sites. Further study of the pathways implicated by these results and future comparisons among populations of T. californicus may help us understand the role and importance of HSF-1 in the heat shock response and, more broadly, in organismal thermal tolerance." @default.
• W3000606908 created "2020-01-23" @default.
• W3000606908 creator A5027547496 @default.
• W3000606908 creator A5060321149 @default.
• W3000606908 date "2020-01-01" @default.
• W3000606908 modified "2023-10-14" @default.
• W3000606908 title "Consequences of <i>HSF</i> knockdown on gene expression during the heat shock response in <i>Tigriopus californicus</i>" @default.
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• W3000606908 doi "https://doi.org/10.1242/jeb.208611" @default.
• W3000606908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34005485" @default.
• W3000606908 hasPublicationYear "2020" @default.
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