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- W3000613202 abstract "Learning objectives After participating in this activity, learners should be better able to: • Identify the effects of dysregulated opioid signalling in depression • Evaluate the use of opioid compounds and ketamine in patients with depression Abstract Major depressive disorder (MDD) remains one of the leading causes of disability and functional impairment worldwide. Current antidepressant therapeutics require weeks to months of treatment prior to the onset of clinical efficacy on depressed mood but remain ineffective in treating suicidal ideation and cognitive impairment. Moreover, 30%–40% of individuals fail to respond to currently available antidepressant medications. MDD is a heterogeneous disorder with an unknown etiology; novel strategies must be developed to treat MDD more effectively. Emerging evidence suggests that targeting one or more of the four opioid receptors—mu (MOR), kappa (KOR), delta (DOR), and the nociceptin/orphanin FQ receptor (NOP)—may yield effective therapeutics for stress-related psychiatric disorders. Furthermore, the effects of the rapidly acting antidepressant ketamine may involve opioid receptors. This review highlights dysregulated opioid signaling in depression, evaluates clinical trials with opioid compounds, and considers the role of opioid mechanisms in rapidly acting antidepressants." @default.
- W3000613202 created "2020-01-23" @default.
- W3000613202 creator A5013552947 @default.
- W3000613202 creator A5036462139 @default.
- W3000613202 creator A5037965214 @default.
- W3000613202 date "2020-01-01" @default.
- W3000613202 modified "2023-10-12" @default.
- W3000613202 title "Novel Targets to Treat Depression: Opioid-Based Therapeutics" @default.
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