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• W3000617445 abstract "Background The relationship between 25-hydroxyvitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations among baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations. Methods Serum 25-OH-vitamin D level was measured in stored samples from 1,609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuously and dichotomized as deficient (< 20 ng/mL) vs not deficient (≥ 20 ng/mL). Outcomes of interest included % predicted FEV1 (current and 1-year longitudinal decline) and COPD exacerbations (separately any and severe, occurring in prior year and first year of follow-up). Results Vitamin D deficiency was present in 21% of the cohort and was more prevalent in the younger, active smokers, and blacks. Vitamin D deficiency was independently associated with lower % predicted FEV1 (by 4.11%) at enrollment (95% CI, –6.90% to –1.34% predicted FEV1; P = .004), 1.27% predicted greater rate of FEV1 decline after 1 year (95% CI, –2.32% to –0.22% predicted/y; P = .02), and higher odds of any COPD exacerbation in the prior year (OR, 1.32; 95% CI, 1.00-1.74; P = .049). Each 10-ng/mL decrease in 25-OH-vitamin D was associated with lower baseline lung function (–1.04% predicted; 95% CI, –1.96% to –0.12% predicted; P = .03) and increased odds of any exacerbation in the year before enrollment (OR, 1.11; 95% CI, 1.01-1.22; P = .04). Conclusions Vitamin D deficiency is associated with worse cross-sectional and longitudinal lung function and increased odds of prior COPD exacerbations. These findings identify 25-OH-vitamin D levels as a potentially useful marker of adverse COPD-related outcomes. The relationship between 25-hydroxyvitamin D (25-OH-vitamin D) and COPD outcomes remains unclear. Using the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), we determined associations among baseline 25-OH-vitamin D and cross-sectional and longitudinal lung function and COPD exacerbations. Serum 25-OH-vitamin D level was measured in stored samples from 1,609 SPIROMICS participants with COPD. 25-OH-vitamin D levels were modeled continuously and dichotomized as deficient (< 20 ng/mL) vs not deficient (≥ 20 ng/mL). Outcomes of interest included % predicted FEV1 (current and 1-year longitudinal decline) and COPD exacerbations (separately any and severe, occurring in prior year and first year of follow-up). Vitamin D deficiency was present in 21% of the cohort and was more prevalent in the younger, active smokers, and blacks. Vitamin D deficiency was independently associated with lower % predicted FEV1 (by 4.11%) at enrollment (95% CI, –6.90% to –1.34% predicted FEV1; P = .004), 1.27% predicted greater rate of FEV1 decline after 1 year (95% CI, –2.32% to –0.22% predicted/y; P = .02), and higher odds of any COPD exacerbation in the prior year (OR, 1.32; 95% CI, 1.00-1.74; P = .049). Each 10-ng/mL decrease in 25-OH-vitamin D was associated with lower baseline lung function (–1.04% predicted; 95% CI, –1.96% to –0.12% predicted; P = .03) and increased odds of any exacerbation in the year before enrollment (OR, 1.11; 95% CI, 1.01-1.22; P = .04). Vitamin D deficiency is associated with worse cross-sectional and longitudinal lung function and increased odds of prior COPD exacerbations. These findings identify 25-OH-vitamin D levels as a potentially useful marker of adverse COPD-related outcomes." @default.
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• W3000617445 date "2020-04-01" @default.
• W3000617445 modified "2023-10-14" @default.
• W3000617445 title "Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD" @default.
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• W3000617445 cites W1982223493 @default.
• W3000617445 cites W1993055974 @default.
• W3000617445 cites W1994680756 @default.
• W3000617445 cites W2036604633 @default.
• W3000617445 cites W2047680613 @default.
• W3000617445 cites W2052497504 @default.
• W3000617445 cites W2097467471 @default.
• W3000617445 cites W2107021471 @default.
• W3000617445 cites W2120397327 @default.
• W3000617445 cites W2122515787 @default.
• W3000617445 cites W2128111531 @default.
• W3000617445 cites W2130462780 @default.
• W3000617445 cites W2134495681 @default.
• W3000617445 cites W2139131213 @default.
• W3000617445 cites W2141978072 @default.
• W3000617445 cites W2152905836 @default.
• W3000617445 cites W2153059487 @default.
• W3000617445 cites W2154559412 @default.
• W3000617445 cites W2157243060 @default.
• W3000617445 cites W2162947611 @default.
• W3000617445 cites W2166254201 @default.
• W3000617445 cites W2166947338 @default.
• W3000617445 cites W2169896557 @default.
• W3000617445 cites W2171676943 @default.
• W3000617445 cites W2300951027 @default.
• W3000617445 cites W2366256932 @default.
• W3000617445 cites W2524508118 @default.
• W3000617445 cites W2536477161 @default.
• W3000617445 cites W2559892788 @default.
• W3000617445 cites W2583959579 @default.
• W3000617445 cites W2606981542 @default.
• W3000617445 cites W2724609343 @default.

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