Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000632106> ?p ?o ?g. }
- W3000632106 abstract "Amyloid deposition is a histological hallmark of common human disorders including Alzheimer’s disease (AD) and type 2 diabetes. Although some reports highlight that amyloid fibrils might activate the innate immunity system via pattern recognition receptors, here we provide multiple lines of evidence for the protection by site-specific amyloid protein analogs and fibrils against autoimmune attacks: (1) strategies targeting clearance of the AD-related brain amyloid plaque induce high risk of deadly autoimmune destructions in subjects with cognitive dysfunction; (2) administration of amyloidogenic peptides with either full length or core hexapeptide structure consistently ameliorates signs of experimental autoimmune encephalomyelitis (EAE); (3) EAE is exacerbated following genetic deletion of amyloid precursor proteins; (4) absence of islet amyloid co-exists with T cell mediated insulitis in autoimmune diabetes and autoimmune polyendocrine syndrome; (5) use of islet amyloid polypeptide agonists rather than antagonists improves diabetes care; and (6) common suppressive signaling pathways by regulatory T cells are activated in both local and systemic amyloidosis. These findings indicate dual modulation activity mediated by amyloid protein monomers, oligomers, and fibrils to maintain immune homeostasis. The protection from autoimmune destruction by amyloid proteins offers a novel therapeutic approach to regenerative medicine for common degenerative diseases." @default.
- W3000632106 created "2020-01-23" @default.
- W3000632106 creator A5002712013 @default.
- W3000632106 creator A5006702094 @default.
- W3000632106 creator A5011995456 @default.
- W3000632106 creator A5018462307 @default.
- W3000632106 creator A5053576816 @default.
- W3000632106 creator A5068440018 @default.
- W3000632106 creator A5072826697 @default.
- W3000632106 date "2020-01-09" @default.
- W3000632106 modified "2023-09-26" @default.
- W3000632106 title "Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses" @default.
- W3000632106 cites W1527636392 @default.
- W3000632106 cites W1535426243 @default.
- W3000632106 cites W1542215809 @default.
- W3000632106 cites W1552209891 @default.
- W3000632106 cites W1554329005 @default.
- W3000632106 cites W1592702941 @default.
- W3000632106 cites W1597614503 @default.
- W3000632106 cites W1745084828 @default.
- W3000632106 cites W1896305101 @default.
- W3000632106 cites W1909502264 @default.
- W3000632106 cites W1942034410 @default.
- W3000632106 cites W1954454186 @default.
- W3000632106 cites W1965799141 @default.
- W3000632106 cites W1967239474 @default.
- W3000632106 cites W1967399741 @default.
- W3000632106 cites W1967642097 @default.
- W3000632106 cites W1968663827 @default.
- W3000632106 cites W1968678331 @default.
- W3000632106 cites W1970577444 @default.
- W3000632106 cites W1974059817 @default.
- W3000632106 cites W1974179395 @default.
- W3000632106 cites W1975481911 @default.
- W3000632106 cites W1976201852 @default.
- W3000632106 cites W1976754924 @default.
- W3000632106 cites W1977011271 @default.
- W3000632106 cites W1978254707 @default.
- W3000632106 cites W1984569087 @default.
- W3000632106 cites W1985142001 @default.
- W3000632106 cites W1986300349 @default.
- W3000632106 cites W1986611577 @default.
- W3000632106 cites W1989734927 @default.
- W3000632106 cites W1990427131 @default.
- W3000632106 cites W1990752558 @default.
- W3000632106 cites W1991763618 @default.
- W3000632106 cites W1991993391 @default.
- W3000632106 cites W1992860518 @default.
- W3000632106 cites W1993976394 @default.
- W3000632106 cites W1994520296 @default.
- W3000632106 cites W1998192343 @default.
- W3000632106 cites W1998840552 @default.
- W3000632106 cites W2000917982 @default.
- W3000632106 cites W2001210466 @default.
- W3000632106 cites W2001398500 @default.
- W3000632106 cites W2002024651 @default.
- W3000632106 cites W2003609792 @default.
- W3000632106 cites W2013363382 @default.
- W3000632106 cites W2014683693 @default.
- W3000632106 cites W2016000332 @default.
- W3000632106 cites W2018593517 @default.
- W3000632106 cites W2018607502 @default.
- W3000632106 cites W2018708829 @default.
- W3000632106 cites W2018803247 @default.
- W3000632106 cites W2019288511 @default.
- W3000632106 cites W2021785060 @default.
- W3000632106 cites W2026077555 @default.
- W3000632106 cites W2026821172 @default.
- W3000632106 cites W2031014005 @default.
- W3000632106 cites W2032487213 @default.
- W3000632106 cites W2033777503 @default.
- W3000632106 cites W2034946303 @default.
- W3000632106 cites W2035391976 @default.
- W3000632106 cites W2035506508 @default.
- W3000632106 cites W2036599501 @default.
- W3000632106 cites W2037248080 @default.
- W3000632106 cites W2039329450 @default.
- W3000632106 cites W2039397725 @default.
- W3000632106 cites W2043679754 @default.
- W3000632106 cites W2043833442 @default.
- W3000632106 cites W2044296849 @default.
- W3000632106 cites W2046093999 @default.
- W3000632106 cites W2046576999 @default.
- W3000632106 cites W2047579358 @default.
- W3000632106 cites W2049167261 @default.
- W3000632106 cites W2051489981 @default.
- W3000632106 cites W2052603766 @default.
- W3000632106 cites W2053116497 @default.
- W3000632106 cites W2053476949 @default.
- W3000632106 cites W2054035555 @default.
- W3000632106 cites W2058432056 @default.
- W3000632106 cites W2059194265 @default.
- W3000632106 cites W2060851420 @default.
- W3000632106 cites W2061685908 @default.
- W3000632106 cites W2064367582 @default.
- W3000632106 cites W2064823979 @default.
- W3000632106 cites W2064874359 @default.
- W3000632106 cites W2065259975 @default.
- W3000632106 cites W2065479473 @default.
- W3000632106 cites W2066792703 @default.