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• W3000686132 abstract "Parathyroid hormone (PTH) enhances cystic fibrosis transmembrane conductance regulator (CFTR)-mediated anion secretion by the human intestinal epithelial cell line Caco-2. With the patch-clamp and Ussing chamber techniques, we investigated how PTH stimulates CFTR activity in Caco-2 cells. Cell-attached recordings revealed that PTH stimulated the opening of CFTR-like channels, while impedance analysis demonstrated that PTH increased apical membrane capacitance, a measure of membrane surface area. Using ion substitution experiments, the PTH-stimulated increase in short-circuit current (Isc), a measure of transepithelial ion transport, was demonstrated to be Cl-- and HCO3--dependent. However, the PTH-stimulated increase in Isc was unaffected by the carbonic anhydrase inhibitor acetazolamide, but partially blocked by the intermediate-conductance Ca2+-activated K+ channel (IKCa) inhibitor clotrimazole. TRAM-34, a related IKCa inhibitor, failed to directly inhibit CFTR Cl- channels in cell-free membrane patches, excluding its action on CFTR. In conclusion, PTH enhances CFTR-mediated anion secretion by Caco-2 monolayers by increasing the expression and function of CFTR in the apical membrane and IKCa activity in the basolateral membrane." @default.
• W3000686132 created "2020-01-23" @default.
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• W3000686132 date "2020-03-01" @default.
• W3000686132 modified "2023-09-24" @default.
• W3000686132 title "Parathyroid hormone increases CFTR expression and function in Caco-2 intestinal epithelial cells" @default.
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• W3000686132 doi "https://doi.org/10.1016/j.bbrc.2019.12.106" @default.
• W3000686132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31954520" @default.
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