FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000688003> ?p ?o ?g. }

• W3000688003 endingPage "332" @default.
• W3000688003 startingPage "315" @default.
• W3000688003 abstract "The clinical outcome of spinal cord injury is usually poor due to the lack of axonal regeneration and glia scar formation. As one of the most classical supporting cells in neural regeneration, Schwann cells (SCs) provide bioactive substrates for axonal migration and release molecules that regulate axonal growth. However, the effect of SC transplantation is limited by their poor migration capacity in the astrocyte-rich central nervous system.In this study, we first magnetofected SCs with chondroitinase ABC-polyethylenimine functionalized superparamagnetic iron oxide nanoparticles (ChABC/PEI-SPIONs) to induce overexpression of ChABC for the removal of chondroitin sulfate proteoglycans. These are inhibitory factors and forming a dense scar that acts as a barrier to the regenerating axons. In vitro, we observed the migration of SCs in the region of astrocytes after the application of a stable external magnetic field.We found that magnetofection with ChABC/PEI-SPIONs significantly up-regulated the expression of ChABC in SCs. Under the driven effect of the directional magnetic field (MF), the migration of magnetofected SCs was enhanced in the direction of the magnetic force. The number of SCs with ChABC/PEI-SPIONs migrated and the distance of migration into the astrocyte region was significantly increased. The number of SCs with ChABC/PEI-SPIONs that migrated into the astrocyte region was 11.6- and 4.6-fold higher than those observed for the intact control and non-MF groups, respectively. Furthermore, it was found that SCs with ChABC/PEI-SPIONs were in close contact with astrocytes and no longer formed boundaries in the presence of MF.The mobility of the SCs with ChABC/PEI-SPIONs was enhanced along the axis of MF, holding the potential to promote nerve regeneration by providing a bioactive microenvironment and relieving glial obstruction to axonal regeneration in the treatment of spinal cord injury." @default.
• W3000688003 created "2020-01-23" @default.
• W3000688003 creator A5003243525 @default.
• W3000688003 creator A5005043215 @default.
• W3000688003 creator A5005294635 @default.
• W3000688003 creator A5007391419 @default.
• W3000688003 creator A5008702674 @default.
• W3000688003 creator A5014555979 @default.
• W3000688003 creator A5028742166 @default.
• W3000688003 creator A5035196583 @default.
• W3000688003 creator A5043768247 @default.
• W3000688003 creator A5060917450 @default.
• W3000688003 creator A5085266293 @default.
• W3000688003 creator A5085575056 @default.
• W3000688003 date "2020-01-01" @default.
• W3000688003 modified "2023-10-16" @default.
• W3000688003 title "<p>Magnetic Field Promotes Migration of Schwann Cells with Chondroitinase ABC (ChABC)-Loaded Superparamagnetic Nanoparticles Across Astrocyte Boundary in vitro</p>" @default.
• W3000688003 cites W119862439 @default.
• W3000688003 cites W1506438655 @default.
• W3000688003 cites W1938236935 @default.
• W3000688003 cites W1964781296 @default.
• W3000688003 cites W1965571714 @default.
• W3000688003 cites W1967517433 @default.
• W3000688003 cites W1968437580 @default.
• W3000688003 cites W1983343963 @default.
• W3000688003 cites W1997721049 @default.
• W3000688003 cites W2008998931 @default.
• W3000688003 cites W2012805705 @default.
• W3000688003 cites W2017343522 @default.
• W3000688003 cites W2021133803 @default.
• W3000688003 cites W2030325542 @default.
• W3000688003 cites W2038215425 @default.
• W3000688003 cites W2044405432 @default.
• W3000688003 cites W2055205487 @default.
• W3000688003 cites W2057873872 @default.
• W3000688003 cites W2061348706 @default.
• W3000688003 cites W2079331102 @default.
• W3000688003 cites W2080089482 @default.
• W3000688003 cites W2082372094 @default.
• W3000688003 cites W2085689721 @default.
• W3000688003 cites W2086442692 @default.
• W3000688003 cites W2096125121 @default.
• W3000688003 cites W2104968232 @default.
• W3000688003 cites W2117775484 @default.
• W3000688003 cites W2118427313 @default.
• W3000688003 cites W2118851633 @default.
• W3000688003 cites W2139870539 @default.
• W3000688003 cites W2141767464 @default.
• W3000688003 cites W2168250283 @default.
• W3000688003 cites W2168854889 @default.
• W3000688003 cites W2303358723 @default.
• W3000688003 cites W2404758544 @default.
• W3000688003 cites W2472757085 @default.
• W3000688003 cites W2509252428 @default.
• W3000688003 cites W2564811695 @default.
• W3000688003 cites W2602502060 @default.
• W3000688003 cites W2616446037 @default.
• W3000688003 cites W2744168996 @default.
• W3000688003 cites W2765463353 @default.
• W3000688003 cites W2766035507 @default.
• W3000688003 cites W2788311383 @default.
• W3000688003 cites W2794351872 @default.
• W3000688003 cites W2795226545 @default.
• W3000688003 cites W2802579564 @default.
• W3000688003 cites W2805491204 @default.
• W3000688003 cites W2807446774 @default.
• W3000688003 cites W2886276190 @default.
• W3000688003 cites W2894892175 @default.
• W3000688003 cites W2908345915 @default.
• W3000688003 cites W2969657221 @default.
• W3000688003 doi "https://doi.org/10.2147/ijn.s227328" @default.
• W3000688003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6980842" @default.
• W3000688003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32021182" @default.
• W3000688003 hasPublicationYear "2020" @default.
• W3000688003 type Work @default.
• W3000688003 sameAs 3000688003 @default.
• W3000688003 citedByCount "14" @default.
• W3000688003 countsByYear W30006880032021 @default.
• W3000688003 countsByYear W30006880032022 @default.
• W3000688003 countsByYear W30006880032023 @default.
• W3000688003 crossrefType "journal-article" @default.
• W3000688003 hasAuthorship W3000688003A5003243525 @default.
• W3000688003 hasAuthorship W3000688003A5005043215 @default.
• W3000688003 hasAuthorship W3000688003A5005294635 @default.
• W3000688003 hasAuthorship W3000688003A5007391419 @default.
• W3000688003 hasAuthorship W3000688003A5008702674 @default.
• W3000688003 hasAuthorship W3000688003A5014555979 @default.
• W3000688003 hasAuthorship W3000688003A5028742166 @default.
• W3000688003 hasAuthorship W3000688003A5035196583 @default.
• W3000688003 hasAuthorship W3000688003A5043768247 @default.
• W3000688003 hasAuthorship W3000688003A5060917450 @default.
• W3000688003 hasAuthorship W3000688003A5085266293 @default.
• W3000688003 hasAuthorship W3000688003A5085575056 @default.
• W3000688003 hasBestOaLocation W30006880031 @default.
• W3000688003 hasConcept C12554922 @default.
• W3000688003 hasConcept C126322002 @default.
• W3000688003 hasConcept C169760540 @default.
• W3000688003 hasConcept C171056886 @default.

• next