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- W3000696985 endingPage "551.e17" @default.
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- W3000696985 abstract "Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning." @default.
- W3000696985 created "2020-01-23" @default.
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- W3000696985 date "2020-02-01" @default.
- W3000696985 modified "2023-10-16" @default.
- W3000696985 title "Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level" @default.
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