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- W3000697673 startingPage "594" @default.
- W3000697673 abstract "Background: Several natural compounds have demonstrated potential for the treatment of central nervous system disorders such as ischemic cerebrovascular disease, glioblastoma, neuropathic pain, neurodegenerative diseases, multiple sclerosis and migraine. This is due to their well-known antioxidant, anti-inflammatory, neuroprotective, anti-tumor, anti-ischemic and analgesic properties. Nevertheless, many of these molecules have poor aqueous solubility, low bioavailability and extensive gastrointestinal and/or hepatic first-pass metabolism, leading to a quick elimination as well as low serum and tissue concentrations. Thus, the intranasal route emerged as a viable alternative to oral or parenteral administration, by enabling a direct transport into the brain through the olfactory and trigeminal nerves. With this approach, the blood-brain barrier is circumvented and peripheral exposure is reduced, thereby minimizing possible adverse effects. Objective: Herein, brain-targeting strategies for nose-to-brain delivery of natural compounds, including flavonoids, cannabinoids, essential oils and terpenes, will be reviewed and discussed. Brain and plasma pharmacokinetics of these molecules will be analyzed and related to their physicochemical characteristics and formulation properties. Conclusion: Natural compounds constitute relevant alternatives for the treatment of brain diseases but often require loading into nanocarrier systems to reach the central nervous system in sufficient concentrations. Future challenges lie in a deeper characterization of their therapeutic mechanisms and in the development of effective, safe and brain-targeted delivery systems for their intranasal administration" @default.
- W3000697673 created "2020-01-23" @default.
- W3000697673 creator A5005211993 @default.
- W3000697673 creator A5005703800 @default.
- W3000697673 creator A5019069584 @default.
- W3000697673 creator A5031340729 @default.
- W3000697673 date "2020-03-20" @default.
- W3000697673 modified "2023-10-14" @default.
- W3000697673 title "Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders" @default.
- W3000697673 cites W1488734028 @default.
- W3000697673 cites W1516644432 @default.
- W3000697673 cites W1808127154 @default.
- W3000697673 cites W1858140691 @default.
- W3000697673 cites W1951827223 @default.
- W3000697673 cites W1965522214 @default.
- W3000697673 cites W1966149946 @default.
- W3000697673 cites W1967033368 @default.
- W3000697673 cites W1967706805 @default.
- W3000697673 cites W1968210553 @default.
- W3000697673 cites W1968213208 @default.
- W3000697673 cites W1971513938 @default.
- W3000697673 cites W1974497548 @default.
- W3000697673 cites W1975187579 @default.
- W3000697673 cites W1977050062 @default.
- W3000697673 cites W1977309653 @default.
- W3000697673 cites W1978912197 @default.
- W3000697673 cites W1985397688 @default.
- W3000697673 cites W1987414585 @default.
- W3000697673 cites W1990357364 @default.
- W3000697673 cites W2004017043 @default.
- W3000697673 cites W2005447377 @default.
- W3000697673 cites W2006349109 @default.
- W3000697673 cites W2006492012 @default.
- W3000697673 cites W2007224996 @default.
- W3000697673 cites W2009979602 @default.
- W3000697673 cites W2010980945 @default.
- W3000697673 cites W2015541518 @default.
- W3000697673 cites W2017076793 @default.
- W3000697673 cites W2019333118 @default.
- W3000697673 cites W2025806954 @default.
- W3000697673 cites W2027692613 @default.
- W3000697673 cites W2029960796 @default.
- W3000697673 cites W2030215451 @default.
- W3000697673 cites W2030737802 @default.
- W3000697673 cites W2030991703 @default.
- W3000697673 cites W2032465380 @default.
- W3000697673 cites W2050758757 @default.
- W3000697673 cites W2051224356 @default.
- W3000697673 cites W2054375471 @default.
- W3000697673 cites W2058780134 @default.
- W3000697673 cites W2061248667 @default.
- W3000697673 cites W2064296617 @default.
- W3000697673 cites W2068312338 @default.
- W3000697673 cites W2073481546 @default.
- W3000697673 cites W2073550498 @default.
- W3000697673 cites W2075752010 @default.
- W3000697673 cites W2078937040 @default.
- W3000697673 cites W2080900363 @default.
- W3000697673 cites W2081927937 @default.
- W3000697673 cites W2082019550 @default.
- W3000697673 cites W2085637809 @default.
- W3000697673 cites W2086626740 @default.
- W3000697673 cites W2087032263 @default.
- W3000697673 cites W2091260251 @default.
- W3000697673 cites W2091425658 @default.
- W3000697673 cites W2094399039 @default.
- W3000697673 cites W2100545066 @default.
- W3000697673 cites W2105455720 @default.
- W3000697673 cites W2109426473 @default.
- W3000697673 cites W2112146861 @default.
- W3000697673 cites W2112222259 @default.
- W3000697673 cites W2113518731 @default.
- W3000697673 cites W2118732639 @default.
- W3000697673 cites W2123050244 @default.
- W3000697673 cites W2124304994 @default.
- W3000697673 cites W2144135270 @default.
- W3000697673 cites W2147981359 @default.
- W3000697673 cites W2148103576 @default.
- W3000697673 cites W2150925905 @default.
- W3000697673 cites W2153571309 @default.
- W3000697673 cites W2156979067 @default.
- W3000697673 cites W2159821105 @default.
- W3000697673 cites W2159879659 @default.
- W3000697673 cites W2160271899 @default.
- W3000697673 cites W2165114272 @default.
- W3000697673 cites W2166846320 @default.
- W3000697673 cites W2169707021 @default.
- W3000697673 cites W2193863667 @default.
- W3000697673 cites W2198267160 @default.
- W3000697673 cites W2280480616 @default.
- W3000697673 cites W2293607107 @default.
- W3000697673 cites W2297606889 @default.
- W3000697673 cites W2313719657 @default.
- W3000697673 cites W2314371091 @default.
- W3000697673 cites W2321980425 @default.
- W3000697673 cites W2397056432 @default.
- W3000697673 cites W2401020722 @default.
- W3000697673 cites W2410246757 @default.