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- W3000714215 abstract "Abstract Micelles are self-assembled core-shell colloidal nanostructures consisting of a hydrophobic core and a hydrophilic corona. Micelles have unique properties including excellent drug payload, longer blood circulation time, relative stability, and biocompatibility. Micelles have been studied extensively as drug delivery systems to improve the efficiency of a variety of therapeutics, particularly anticancer drugs. Recently, in oncology, combinational therapy has generated much attention from pharmaceutical scientists hoping to combine efficient treatment with reduced side effects. The possibility of encapsulating various therapeutics within a single particle makes micelles desirable candidate for multidrug delivery systems in combination therapy. Micelles loaded with different/multiple chemotherapy agents provide the opportunity for development of synergistic anticancer effects, suppression of multidrug resistance, modified drug release profiles, improved pharmacokinetics, and reduced dose-dependent toxicity. In addition, multiple drug-loaded micelles have been used widely in the design of targeted drug delivery systems by the attachment of targeting agents along with the chemotherapeutics. Micelles that can concurrently deliver multiple types of agents provide the opportunity to combine chemotherapy with other therapies including radiotherapy, immune therapy, and photothermal therapy. This chapter focuses on polymeric micelles as multidrug delivery systems to address corresponding opportunities, challenges, and prospects for cancer chemotherapy." @default.
- W3000714215 created "2020-01-23" @default.
- W3000714215 creator A5054577930 @default.
- W3000714215 creator A5084391530 @default.
- W3000714215 date "2020-01-01" @default.
- W3000714215 modified "2023-09-27" @default.
- W3000714215 title "Polymeric nanomicelles as versatile tool for multidrug delivery in chemotherapy" @default.
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