Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000714459> ?p ?o ?g. }
- W3000714459 endingPage "320" @default.
- W3000714459 startingPage "312" @default.
- W3000714459 abstract "The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases. Materials and methods. The study was performed on sexually mature male Wistar rats. Endothelial dysfunction was modulated by a 7-days intraperitoneal administration of L-NAME at the dose of 2.5 mg/100 g. P-αB, or erythropoietin (EPO), was used for therapy at the dose of 2.5 µg/100 g × 3 times for 7 days, the total dose was 7.5 µg/100 g. The function of endothelium was estimated by an endothelium-dependent and endothelium-independent vasodilation. In addition, a histological assessment of the abdominal aortic wall state and the analysis of eNos , Tnf and Il-1 β genes expression were performed. To estimate prothrombotic properties, P-αB and EPO were administered, at the doses of 2.5 and 5 µg/100 g (3 times a day for 7 days, the total doses were 7.5 µg/100 g and 15 µg/100 g, respectively) and on the 8th day, the time of ferric (III) chloride-induced carotid artery thrombosis was estimated. Results. Theresults of the functional tests for endothelium-dependent and endothelium-independent vasodilatation, as well as the histological picture of the aorta have evidenced that P-αB and EPO do not affect L-NAME-induced hypertension but improve the endothelium function. At the same time, P-αB shows a significantly higher endothelial-protective activity, reducing the coefficient of endothelial dysfunction from 5.1±0.15 to 2.72±0.12. In addition, P-αB has significantly increased the expression of eNos and reduced the expression level of Tnf and Il-1 β mRNA genes. Carrying out Ferric (III) chloride-induced carotid artery thrombosis has revealed that P-αB (5 µg/100 g × 3 times a day for 7 days, total dose was 15 µg/100 g) has a lower but statistically significant prothrombotic activity than EPO. Conclusion. P-αB can be positioned as an atheroprotector because of its ability to prevent the death of endothelial cells, as well as to reduce remodeling and proinflammatory activation of the vascular wall. However, the prothrombotic properties of P-αB limit its use as a preventing and treating agent for atherosclerosis-associated diseases." @default.
- W3000714459 created "2020-01-23" @default.
- W3000714459 creator A5002804662 @default.
- W3000714459 creator A5017129161 @default.
- W3000714459 creator A5022389175 @default.
- W3000714459 creator A5027960618 @default.
- W3000714459 creator A5037110251 @default.
- W3000714459 creator A5038252391 @default.
- W3000714459 creator A5040668550 @default.
- W3000714459 creator A5041674094 @default.
- W3000714459 creator A5048148028 @default.
- W3000714459 creator A5048778963 @default.
- W3000714459 creator A5049548635 @default.
- W3000714459 creator A5049684166 @default.
- W3000714459 creator A5057604582 @default.
- W3000714459 creator A5075427084 @default.
- W3000714459 date "2020-01-17" @default.
- W3000714459 modified "2023-09-27" @default.
- W3000714459 title "11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats." @default.
- W3000714459 cites W192471487 @default.
- W3000714459 cites W1967334494 @default.
- W3000714459 cites W2012330153 @default.
- W3000714459 cites W2022805013 @default.
- W3000714459 cites W2032831426 @default.
- W3000714459 cites W2036417393 @default.
- W3000714459 cites W2038450085 @default.
- W3000714459 cites W2046119060 @default.
- W3000714459 cites W2136847598 @default.
- W3000714459 cites W2161854192 @default.
- W3000714459 cites W2170209770 @default.
- W3000714459 cites W2275204317 @default.
- W3000714459 cites W2336812263 @default.
- W3000714459 cites W2585936619 @default.
- W3000714459 cites W2739449149 @default.
- W3000714459 cites W2901522840 @default.
- W3000714459 cites W2968068333 @default.
- W3000714459 cites W2990542525 @default.
- W3000714459 cites W2997050743 @default.
- W3000714459 cites W4237990927 @default.
- W3000714459 doi "https://doi.org/10.19163/2307-9266-2019-7-6-312-320" @default.
- W3000714459 hasPublicationYear "2020" @default.
- W3000714459 type Work @default.
- W3000714459 sameAs 3000714459 @default.
- W3000714459 citedByCount "10" @default.
- W3000714459 countsByYear W30007144592020 @default.
- W3000714459 countsByYear W30007144592021 @default.
- W3000714459 countsByYear W30007144592022 @default.
- W3000714459 countsByYear W30007144592023 @default.
- W3000714459 crossrefType "journal-article" @default.
- W3000714459 hasAuthorship W3000714459A5002804662 @default.
- W3000714459 hasAuthorship W3000714459A5017129161 @default.
- W3000714459 hasAuthorship W3000714459A5022389175 @default.
- W3000714459 hasAuthorship W3000714459A5027960618 @default.
- W3000714459 hasAuthorship W3000714459A5037110251 @default.
- W3000714459 hasAuthorship W3000714459A5038252391 @default.
- W3000714459 hasAuthorship W3000714459A5040668550 @default.
- W3000714459 hasAuthorship W3000714459A5041674094 @default.
- W3000714459 hasAuthorship W3000714459A5048148028 @default.
- W3000714459 hasAuthorship W3000714459A5048778963 @default.
- W3000714459 hasAuthorship W3000714459A5049548635 @default.
- W3000714459 hasAuthorship W3000714459A5049684166 @default.
- W3000714459 hasAuthorship W3000714459A5057604582 @default.
- W3000714459 hasAuthorship W3000714459A5075427084 @default.
- W3000714459 hasBestOaLocation W30007144591 @default.
- W3000714459 hasConcept C120770815 @default.
- W3000714459 hasConcept C126322002 @default.
- W3000714459 hasConcept C134018914 @default.
- W3000714459 hasConcept C2776992346 @default.
- W3000714459 hasConcept C2777622882 @default.
- W3000714459 hasConcept C2778326061 @default.
- W3000714459 hasConcept C2778534260 @default.
- W3000714459 hasConcept C2780868729 @default.
- W3000714459 hasConcept C2780972559 @default.
- W3000714459 hasConcept C519581460 @default.
- W3000714459 hasConcept C71924100 @default.
- W3000714459 hasConcept C98274493 @default.
- W3000714459 hasConceptScore W3000714459C120770815 @default.
- W3000714459 hasConceptScore W3000714459C126322002 @default.
- W3000714459 hasConceptScore W3000714459C134018914 @default.
- W3000714459 hasConceptScore W3000714459C2776992346 @default.
- W3000714459 hasConceptScore W3000714459C2777622882 @default.
- W3000714459 hasConceptScore W3000714459C2778326061 @default.
- W3000714459 hasConceptScore W3000714459C2778534260 @default.
- W3000714459 hasConceptScore W3000714459C2780868729 @default.
- W3000714459 hasConceptScore W3000714459C2780972559 @default.
- W3000714459 hasConceptScore W3000714459C519581460 @default.
- W3000714459 hasConceptScore W3000714459C71924100 @default.
- W3000714459 hasConceptScore W3000714459C98274493 @default.
- W3000714459 hasIssue "6" @default.
- W3000714459 hasLocation W30007144591 @default.
- W3000714459 hasLocation W30007144592 @default.
- W3000714459 hasOpenAccess W3000714459 @default.
- W3000714459 hasPrimaryLocation W30007144591 @default.
- W3000714459 hasRelatedWork W1967017723 @default.
- W3000714459 hasRelatedWork W1983537588 @default.
- W3000714459 hasRelatedWork W2028343319 @default.
- W3000714459 hasRelatedWork W2066352140 @default.
- W3000714459 hasRelatedWork W2097749927 @default.