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- W3000714690 endingPage "110638" @default.
- W3000714690 startingPage "110638" @default.
- W3000714690 abstract "Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). The delivery of drugs through nanomedicines combined with less invasive alternative therapies represents an important hope for the future of these incurable brain tumors. Whey protein nanocarriers represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug's bioavailability and distribution, and reducing the body's response towards drug resistance. They have been extensively studied to find new alternatives for capacity to encapsulate different drugs and no need for cross-linkers. In this study, we report for the first time the incorporation and administration of Aluminum phthalocyanine chloride (AlClPc)-loaded whey protein drug delivery system (AlClPc-PDDS) for the treatment of glioblastoma brain cancer. This system was designed and optimized (with the use of the spray drying technique) to obtain the required particle size (in the range of 100 to 300 nm), zeta potential and drug loading. Our results suggest that we have developed a drug delivery system from a low-cost raw material and preparation method that is capable of incorporating hydrophobic drugs which, in combination with irradiation, cause photodamage to neoplasic cells, working as an effective adjuvant treatment for malignant glioma." @default.
- W3000714690 created "2020-01-23" @default.
- W3000714690 creator A5030935347 @default.
- W3000714690 creator A5037671237 @default.
- W3000714690 creator A5074558889 @default.
- W3000714690 date "2020-05-01" @default.
- W3000714690 modified "2023-10-17" @default.
- W3000714690 title "Design of new protein drug delivery system (PDDS) with photoactive compounds as a potential application in the treatment of glioblastoma brain cancer" @default.
- W3000714690 cites W1629179716 @default.
- W3000714690 cites W1783963600 @default.
- W3000714690 cites W1839629440 @default.
- W3000714690 cites W1841201983 @default.
- W3000714690 cites W1964019697 @default.
- W3000714690 cites W1966434015 @default.
- W3000714690 cites W1972840121 @default.
- W3000714690 cites W1977690507 @default.
- W3000714690 cites W1981707250 @default.
- W3000714690 cites W1986421799 @default.
- W3000714690 cites W1987537515 @default.
- W3000714690 cites W1992891617 @default.
- W3000714690 cites W1998941426 @default.
- W3000714690 cites W2000539628 @default.
- W3000714690 cites W2004423725 @default.
- W3000714690 cites W2005066650 @default.
- W3000714690 cites W2007534995 @default.
- W3000714690 cites W2009713553 @default.
- W3000714690 cites W2012150747 @default.
- W3000714690 cites W2012506930 @default.
- W3000714690 cites W2021300711 @default.
- W3000714690 cites W2028062716 @default.
- W3000714690 cites W2034808342 @default.
- W3000714690 cites W2035552013 @default.
- W3000714690 cites W2037555314 @default.
- W3000714690 cites W2037642785 @default.
- W3000714690 cites W2040842099 @default.
- W3000714690 cites W2046589940 @default.
- W3000714690 cites W2046724529 @default.
- W3000714690 cites W2051094981 @default.
- W3000714690 cites W2054842174 @default.
- W3000714690 cites W2056402122 @default.
- W3000714690 cites W2058761250 @default.
- W3000714690 cites W2063043992 @default.
- W3000714690 cites W2065768837 @default.
- W3000714690 cites W2066742760 @default.
- W3000714690 cites W2069451956 @default.
- W3000714690 cites W2071070214 @default.
- W3000714690 cites W2071215562 @default.
- W3000714690 cites W2071578270 @default.
- W3000714690 cites W2072298860 @default.
- W3000714690 cites W2076761483 @default.
- W3000714690 cites W2080198053 @default.
- W3000714690 cites W2081622422 @default.
- W3000714690 cites W2082639021 @default.
- W3000714690 cites W2084711500 @default.
- W3000714690 cites W2089222447 @default.
- W3000714690 cites W2093624389 @default.
- W3000714690 cites W2112135623 @default.
- W3000714690 cites W2114334126 @default.
- W3000714690 cites W2118476975 @default.
- W3000714690 cites W2120979011 @default.
- W3000714690 cites W2129551032 @default.
- W3000714690 cites W2129937740 @default.
- W3000714690 cites W2135025266 @default.
- W3000714690 cites W2139212129 @default.
- W3000714690 cites W2142700445 @default.
- W3000714690 cites W2148126501 @default.
- W3000714690 cites W2151734986 @default.
- W3000714690 cites W2160382843 @default.
- W3000714690 cites W2195473998 @default.
- W3000714690 cites W2274284565 @default.
- W3000714690 cites W2293461885 @default.
- W3000714690 cites W2314481464 @default.
- W3000714690 cites W2320574135 @default.
- W3000714690 cites W2331874435 @default.
- W3000714690 cites W2337851280 @default.
- W3000714690 cites W2341595153 @default.
- W3000714690 cites W2345211320 @default.
- W3000714690 cites W2366536035 @default.
- W3000714690 cites W2469770473 @default.
- W3000714690 cites W2500974569 @default.
- W3000714690 cites W2515041602 @default.
- W3000714690 cites W2517137330 @default.
- W3000714690 cites W2535930207 @default.
- W3000714690 cites W2548357873 @default.
- W3000714690 cites W2553258882 @default.
- W3000714690 cites W2555156914 @default.
- W3000714690 cites W2565295747 @default.
- W3000714690 cites W2567398071 @default.
- W3000714690 cites W2570302619 @default.
- W3000714690 cites W2580826593 @default.
- W3000714690 cites W2597487608 @default.
- W3000714690 cites W2619656879 @default.
- W3000714690 cites W2725110408 @default.
- W3000714690 cites W2733667023 @default.
- W3000714690 cites W2745880135 @default.
- W3000714690 cites W2765507447 @default.
- W3000714690 cites W2772393177 @default.
- W3000714690 cites W2791335613 @default.