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• W3000725902 abstract "We report that naturally protected HSV-1-seropositive asymptomatic individuals develop a higher frequency of antiviral effector memory CD4 + T EM cells specific to two immunodominant epitopes derived from the HSV-1 tegument protein VP11/12. Immunization of HLA-DR transgenic mice with a mixture of these two immunodominant CD4 + T cell epitopes induced a robust antiviral CD4 + T cell response in the cornea that was associated with protective immunity against ocular herpes. The emerging concept of developing an asymptomatic herpes vaccine that would boost effector memory CD4 + and CD8 + T EM cell responses is discussed." @default.
• W3000725902 created "2020-01-23" @default.
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• W3000725902 creator A5089139258 @default.
• W3000725902 date "2020-03-17" @default.
• W3000725902 modified "2023-10-09" @default.
• W3000725902 title "Human Epitopes Identified from Herpes Simplex Virus Tegument Protein VP11/12 (UL46) Recall Multifunctional Effector Memory CD4⁺T_EMCells in Asymptomatic Individuals and Protect from Ocular Herpes Infection and Disease in “Humanized” HLA-DR Transgenic Mice" @default.
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• W3000725902 doi "https://doi.org/10.1128/jvi.01991-19" @default.
• W3000725902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7081904" @default.
• W3000725902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31915285" @default.
• W3000725902 hasPublicationYear "2020" @default.
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