Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000726711> ?p ?o ?g. }
- W3000726711 endingPage "1901366" @default.
- W3000726711 startingPage "1901366" @default.
- W3000726711 abstract "Oncogenic transformation of mammary epithelial cells (MECs) is a critical step in epithelial-to-mesenchymal transition (EMT), but evidence also shows that MECs undergo EMT with increasing matrix stiffness; the interplay of genetic and environmental effects on EMT is not clear. To understand their combinatorial effects on EMT, premalignant MCF10A and isogenic Ras-transformed MCF10AT are cultured on polyacrylamide gels ranging from normal mammary stiffness, ≈150 Pa, to tumor stiffness, ≈5700 Pa. Though cells spread on stiff hydrogels independent of transformation, only 10AT cells exhibit heterogeneous spreading behavior on soft hydrogels. Within this mixed population, spread cells exhibit an elongated, mesenchymal-like morphology, disrupted localization of the basement membrane, and nuclear localization of the EMT transcription factor TWIST1. MCF10AT spreading is not driven by typical mechanosensitive pathways including YAP and TGF-β or by myosin contraction. Rather, ERK activation induces spreading of MCF10AT cells on soft hydrogels and requires dynamic microtubules. These findings indicate the importance of oncogenic signals, and their hierarchy with substrate mechanics, in regulating MEC EMT." @default.
- W3000726711 created "2020-01-23" @default.
- W3000726711 creator A5001538757 @default.
- W3000726711 creator A5003559800 @default.
- W3000726711 creator A5039405858 @default.
- W3000726711 creator A5042823998 @default.
- W3000726711 creator A5068026851 @default.
- W3000726711 creator A5071892023 @default.
- W3000726711 creator A5086699418 @default.
- W3000726711 date "2020-01-17" @default.
- W3000726711 modified "2023-10-15" @default.
- W3000726711 title "H‐Ras Transformation of Mammary Epithelial Cells Induces ERK‐Mediated Spreading on Low Stiffness Matrix" @default.
- W3000726711 cites W1964847767 @default.
- W3000726711 cites W1967293289 @default.
- W3000726711 cites W1975475567 @default.
- W3000726711 cites W1988100553 @default.
- W3000726711 cites W1992348966 @default.
- W3000726711 cites W2011826559 @default.
- W3000726711 cites W2024315189 @default.
- W3000726711 cites W2027345413 @default.
- W3000726711 cites W2029526500 @default.
- W3000726711 cites W2031193906 @default.
- W3000726711 cites W2099052265 @default.
- W3000726711 cites W2101728107 @default.
- W3000726711 cites W2103957479 @default.
- W3000726711 cites W2146337514 @default.
- W3000726711 cites W2167100625 @default.
- W3000726711 cites W2275768000 @default.
- W3000726711 cites W2539424880 @default.
- W3000726711 cites W2730718150 @default.
- W3000726711 cites W2793589490 @default.
- W3000726711 cites W2795582992 @default.
- W3000726711 cites W2888628838 @default.
- W3000726711 cites W2904869203 @default.
- W3000726711 cites W2914239820 @default.
- W3000726711 cites W2914936371 @default.
- W3000726711 doi "https://doi.org/10.1002/adhm.201901366" @default.
- W3000726711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7274860" @default.
- W3000726711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31951109" @default.
- W3000726711 hasPublicationYear "2020" @default.
- W3000726711 type Work @default.
- W3000726711 sameAs 3000726711 @default.
- W3000726711 citedByCount "7" @default.
- W3000726711 countsByYear W30007267112020 @default.
- W3000726711 countsByYear W30007267112021 @default.
- W3000726711 countsByYear W30007267112022 @default.
- W3000726711 countsByYear W30007267112023 @default.
- W3000726711 crossrefType "journal-article" @default.
- W3000726711 hasAuthorship W3000726711A5001538757 @default.
- W3000726711 hasAuthorship W3000726711A5003559800 @default.
- W3000726711 hasAuthorship W3000726711A5039405858 @default.
- W3000726711 hasAuthorship W3000726711A5042823998 @default.
- W3000726711 hasAuthorship W3000726711A5068026851 @default.
- W3000726711 hasAuthorship W3000726711A5071892023 @default.
- W3000726711 hasAuthorship W3000726711A5086699418 @default.
- W3000726711 hasBestOaLocation W30007267111 @default.
- W3000726711 hasConcept C104317684 @default.
- W3000726711 hasConcept C108586683 @default.
- W3000726711 hasConcept C127561419 @default.
- W3000726711 hasConcept C170493617 @default.
- W3000726711 hasConcept C178790620 @default.
- W3000726711 hasConcept C185592680 @default.
- W3000726711 hasConcept C189165786 @default.
- W3000726711 hasConcept C198826908 @default.
- W3000726711 hasConcept C2908647359 @default.
- W3000726711 hasConcept C4001165 @default.
- W3000726711 hasConcept C50254741 @default.
- W3000726711 hasConcept C55493867 @default.
- W3000726711 hasConcept C71924100 @default.
- W3000726711 hasConcept C76419328 @default.
- W3000726711 hasConcept C86803240 @default.
- W3000726711 hasConcept C95444343 @default.
- W3000726711 hasConcept C99454951 @default.
- W3000726711 hasConceptScore W3000726711C104317684 @default.
- W3000726711 hasConceptScore W3000726711C108586683 @default.
- W3000726711 hasConceptScore W3000726711C127561419 @default.
- W3000726711 hasConceptScore W3000726711C170493617 @default.
- W3000726711 hasConceptScore W3000726711C178790620 @default.
- W3000726711 hasConceptScore W3000726711C185592680 @default.
- W3000726711 hasConceptScore W3000726711C189165786 @default.
- W3000726711 hasConceptScore W3000726711C198826908 @default.
- W3000726711 hasConceptScore W3000726711C2908647359 @default.
- W3000726711 hasConceptScore W3000726711C4001165 @default.
- W3000726711 hasConceptScore W3000726711C50254741 @default.
- W3000726711 hasConceptScore W3000726711C55493867 @default.
- W3000726711 hasConceptScore W3000726711C71924100 @default.
- W3000726711 hasConceptScore W3000726711C76419328 @default.
- W3000726711 hasConceptScore W3000726711C86803240 @default.
- W3000726711 hasConceptScore W3000726711C95444343 @default.
- W3000726711 hasConceptScore W3000726711C99454951 @default.
- W3000726711 hasFunder F4320332161 @default.
- W3000726711 hasFunder F4320337338 @default.
- W3000726711 hasFunder F4320337351 @default.
- W3000726711 hasFunder F4320337362 @default.
- W3000726711 hasFunder F4320337391 @default.
- W3000726711 hasFunder F4320338273 @default.
- W3000726711 hasIssue "8" @default.
- W3000726711 hasLocation W30007267111 @default.