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- W3000732612 abstract "Meroterpenoids are natural products of hybrid biosynthetic origins-derived from both terpenoid and polyketide pathways-with a wealth of biological activities. Given their therapeutic potential, a general strategy to access these natural products in a concise and divergent fashion is highly desirable. Here, we report a modular synthesis of a suite of oxidized meroterpenoids using a hybrid synthetic strategy that is designed to harness the power of both biocatalytic and radical-based retrosynthetic logic. This strategy enables direct introduction of key hydroxyl groups and rapid construction of key bonds and stereocentres, facilitating the development of a concise route (7-12 steps from commercial materials) to eight oxidized meroterpenoids from two common molecular scaffolds. This work lays the foundation for rapid access to a wide range of oxidized meroterpenoids through the use of similar hybrid strategy that combines two synthetic approaches." @default.
- W3000732612 created "2020-01-23" @default.
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- W3000732612 date "2020-01-20" @default.
- W3000732612 modified "2023-09-30" @default.
- W3000732612 title "Merging chemoenzymatic and radical-based retrosynthetic logic for rapid and modular synthesis of oxidized meroterpenoids" @default.
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- W3000732612 doi "https://doi.org/10.1038/s41557-019-0407-6" @default.
- W3000732612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7250629" @default.
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