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- W3000736032 endingPage "191316" @default.
- W3000736032 startingPage "191316" @default.
- W3000736032 abstract "Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3′,4′-dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones, designed as molecular hybrids of THIQ and OX, were synthesized and screened in vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukaemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents." @default.
- W3000736032 created "2020-01-23" @default.
- W3000736032 creator A5027697360 @default.
- W3000736032 creator A5081978579 @default.
- W3000736032 date "2020-01-01" @default.
- W3000736032 modified "2023-10-10" @default.
- W3000736032 title "3′,4′-Dihydro-2′H-spiro[indoline-3,1′-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening" @default.
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- W3000736032 doi "https://doi.org/10.1098/rsos.191316" @default.
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