FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000736801> ?p ?o ?g. }

• W3000736801 endingPage "145" @default.
• W3000736801 startingPage "145" @default.
• W3000736801 abstract "Protein aggregation is associated with an increasing number of human disorders and premature aging. Moreover, it is a central concern in the manufacturing of recombinant proteins for biotechnological and therapeutic applications. Nevertheless, the unique architecture of protein aggregates is also exploited by nature for functional purposes, from bacteria to humans. The relevance of this process in health and disease has boosted the interest in understanding and controlling aggregation, with the concomitant development of a myriad of algorithms aimed to predict aggregation propensities. However, most of these programs are blind to the protein environment and, in particular, to the influence of the pH. Here, we developed an empirical equation to model the pH-dependent aggregation of intrinsically disordered proteins (IDPs) based on the assumption that both the global protein charge and lipophilicity depend on the solution pH. Upon its parametrization with a model IDP, this simple phenomenological approach showed unprecedented accuracy in predicting the dependence of the aggregation of both pathogenic and functional amyloidogenic IDPs on the pH. The algorithm might be useful for diverse applications, from large-scale analysis of IDPs aggregation properties to the design of novel reversible nanofibrillar materials." @default.
• W3000736801 created "2020-01-23" @default.
• W3000736801 creator A5002785720 @default.
• W3000736801 creator A5012807945 @default.
• W3000736801 creator A5022075257 @default.
• W3000736801 creator A5024812664 @default.
• W3000736801 creator A5025858582 @default.
• W3000736801 creator A5085698870 @default.
• W3000736801 creator A5088109143 @default.
• W3000736801 date "2020-01-08" @default.
• W3000736801 modified "2023-10-18" @default.
• W3000736801 title "pH-Dependent Aggregation in Intrinsically Disordered Proteins Is Determined by Charge and Lipophilicity" @default.
• W3000736801 cites W1525659758 @default.
• W3000736801 cites W1527671059 @default.
• W3000736801 cites W1580609715 @default.
• W3000736801 cites W1584032701 @default.
• W3000736801 cites W1963994022 @default.
• W3000736801 cites W1965420960 @default.
• W3000736801 cites W1971862042 @default.
• W3000736801 cites W1972260684 @default.
• W3000736801 cites W1979591162 @default.
• W3000736801 cites W1991356605 @default.
• W3000736801 cites W2005763227 @default.
• W3000736801 cites W2012108346 @default.
• W3000736801 cites W2014875724 @default.
• W3000736801 cites W2027839322 @default.
• W3000736801 cites W2030450209 @default.
• W3000736801 cites W2030591146 @default.
• W3000736801 cites W2031927717 @default.
• W3000736801 cites W2031958434 @default.
• W3000736801 cites W2033853317 @default.
• W3000736801 cites W2034942377 @default.
• W3000736801 cites W2043876754 @default.
• W3000736801 cites W2046093999 @default.
• W3000736801 cites W2049391304 @default.
• W3000736801 cites W2059797637 @default.
• W3000736801 cites W2073948759 @default.
• W3000736801 cites W2074726906 @default.
• W3000736801 cites W2080751623 @default.
• W3000736801 cites W2080831965 @default.
• W3000736801 cites W2082314807 @default.
• W3000736801 cites W2086272648 @default.
• W3000736801 cites W2089522371 @default.
• W3000736801 cites W2096324068 @default.
• W3000736801 cites W2127686159 @default.
• W3000736801 cites W2133425057 @default.
• W3000736801 cites W2134439639 @default.
• W3000736801 cites W2137209317 @default.
• W3000736801 cites W2144134833 @default.
• W3000736801 cites W2146773519 @default.
• W3000736801 cites W2157873167 @default.
• W3000736801 cites W2165186407 @default.
• W3000736801 cites W2209022283 @default.
• W3000736801 cites W2291424369 @default.
• W3000736801 cites W2324575072 @default.
• W3000736801 cites W2330831003 @default.
• W3000736801 cites W2331288560 @default.
• W3000736801 cites W2382261180 @default.
• W3000736801 cites W2463717668 @default.
• W3000736801 cites W2468157290 @default.
• W3000736801 cites W2555151293 @default.
• W3000736801 cites W2605907919 @default.
• W3000736801 cites W2614053601 @default.
• W3000736801 cites W2619203867 @default.
• W3000736801 cites W2739654398 @default.
• W3000736801 cites W2751940688 @default.
• W3000736801 cites W2757687713 @default.
• W3000736801 cites W2782130029 @default.
• W3000736801 cites W2790970165 @default.
• W3000736801 cites W2793694199 @default.
• W3000736801 cites W2807030704 @default.
• W3000736801 cites W2807638149 @default.
• W3000736801 cites W2884865065 @default.
• W3000736801 cites W2891688080 @default.
• W3000736801 cites W2898457355 @default.
• W3000736801 cites W2912694753 @default.
• W3000736801 cites W291592151 @default.
• W3000736801 cites W2919319795 @default.
• W3000736801 cites W2943407516 @default.
• W3000736801 cites W2968895639 @default.
• W3000736801 cites W2974717956 @default.
• W3000736801 cites W4235875658 @default.
• W3000736801 doi "https://doi.org/10.3390/cells9010145" @default.
• W3000736801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7017033" @default.
• W3000736801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31936201" @default.
• W3000736801 hasPublicationYear "2020" @default.
• W3000736801 type Work @default.
• W3000736801 sameAs 3000736801 @default.
• W3000736801 citedByCount "36" @default.
• W3000736801 countsByYear W30007368012020 @default.
• W3000736801 countsByYear W30007368012021 @default.
• W3000736801 countsByYear W30007368012022 @default.
• W3000736801 countsByYear W30007368012023 @default.
• W3000736801 crossrefType "journal-article" @default.
• W3000736801 hasAuthorship W3000736801A5002785720 @default.
• W3000736801 hasAuthorship W3000736801A5012807945 @default.
• W3000736801 hasAuthorship W3000736801A5022075257 @default.
• W3000736801 hasAuthorship W3000736801A5024812664 @default.

• next