Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000736974> ?p ?o ?g. }
- W3000736974 endingPage "426.e16" @default.
- W3000736974 startingPage "411" @default.
- W3000736974 abstract "Stress granules are condensates of non-translating mRNAs and proteins involved in the stress response and neurodegenerative diseases. Stress granules form in part through intermolecular RNA-RNA interactions, and to better understand how RNA-based condensation occurs, we demonstrate that RNA is effectively recruited to the surfaces of RNA or RNP condensates in vitro. We demonstrate that, through ATP-dependent RNA binding, the DEAD-box protein eIF4A reduces RNA condensation in vitro and limits stress granule formation in cells. This defines a function for eIF4A to limit intermolecular RNA-RNA interactions in cells. These results establish an important role for eIF4A, and potentially other DEAD-box proteins, as ATP-dependent RNA chaperones that limit the condensation of RNA, analogous to the function of proteins like HSP70 in combatting protein aggregates." @default.
- W3000736974 created "2020-01-23" @default.
- W3000736974 creator A5003180767 @default.
- W3000736974 creator A5014796446 @default.
- W3000736974 creator A5032768593 @default.
- W3000736974 creator A5059469974 @default.
- W3000736974 creator A5077606106 @default.
- W3000736974 creator A5016800388 @default.
- W3000736974 date "2020-02-01" @default.
- W3000736974 modified "2023-10-15" @default.
- W3000736974 title "Modulation of RNA Condensation by the DEAD-Box Protein eIF4A" @default.
- W3000736974 cites W1062427742 @default.
- W3000736974 cites W1763659965 @default.
- W3000736974 cites W1964099889 @default.
- W3000736974 cites W1968715156 @default.
- W3000736974 cites W1972249656 @default.
- W3000736974 cites W1973556963 @default.
- W3000736974 cites W1987607631 @default.
- W3000736974 cites W1997493439 @default.
- W3000736974 cites W2013482681 @default.
- W3000736974 cites W2014028277 @default.
- W3000736974 cites W2017043601 @default.
- W3000736974 cites W2020099265 @default.
- W3000736974 cites W2024536332 @default.
- W3000736974 cites W2037456549 @default.
- W3000736974 cites W2038652232 @default.
- W3000736974 cites W2039779096 @default.
- W3000736974 cites W2039792018 @default.
- W3000736974 cites W2059997993 @default.
- W3000736974 cites W2062289554 @default.
- W3000736974 cites W2065868028 @default.
- W3000736974 cites W2068868065 @default.
- W3000736974 cites W2078532539 @default.
- W3000736974 cites W2084702659 @default.
- W3000736974 cites W2085697301 @default.
- W3000736974 cites W2086815629 @default.
- W3000736974 cites W2092751120 @default.
- W3000736974 cites W2103635033 @default.
- W3000736974 cites W2105437577 @default.
- W3000736974 cites W2106100778 @default.
- W3000736974 cites W2107680358 @default.
- W3000736974 cites W2110739636 @default.
- W3000736974 cites W2114921531 @default.
- W3000736974 cites W2125655241 @default.
- W3000736974 cites W2129183636 @default.
- W3000736974 cites W2131187223 @default.
- W3000736974 cites W2131445177 @default.
- W3000736974 cites W2138397691 @default.
- W3000736974 cites W2140208297 @default.
- W3000736974 cites W2141465442 @default.
- W3000736974 cites W2143069387 @default.
- W3000736974 cites W2145854488 @default.
- W3000736974 cites W2146503498 @default.
- W3000736974 cites W2155632240 @default.
- W3000736974 cites W2155639426 @default.
- W3000736974 cites W2157258464 @default.
- W3000736974 cites W2158855280 @default.
- W3000736974 cites W2165962849 @default.
- W3000736974 cites W2167279371 @default.
- W3000736974 cites W2236156346 @default.
- W3000736974 cites W2311204218 @default.
- W3000736974 cites W2388201280 @default.
- W3000736974 cites W2402791934 @default.
- W3000736974 cites W2416403255 @default.
- W3000736974 cites W2419532700 @default.
- W3000736974 cites W2514582647 @default.
- W3000736974 cites W2522982067 @default.
- W3000736974 cites W2527809167 @default.
- W3000736974 cites W2573507107 @default.
- W3000736974 cites W2580035316 @default.
- W3000736974 cites W2590568317 @default.
- W3000736974 cites W2617594926 @default.
- W3000736974 cites W2756821926 @default.
- W3000736974 cites W2759609596 @default.
- W3000736974 cites W2765664383 @default.
- W3000736974 cites W2767613320 @default.
- W3000736974 cites W2773704015 @default.
- W3000736974 cites W2776559018 @default.
- W3000736974 cites W2780438117 @default.
- W3000736974 cites W2784241249 @default.
- W3000736974 cites W2784370070 @default.
- W3000736974 cites W2784401093 @default.
- W3000736974 cites W2791055994 @default.
- W3000736974 cites W2791482849 @default.
- W3000736974 cites W2796037415 @default.
- W3000736974 cites W2802015040 @default.
- W3000736974 cites W2808136147 @default.
- W3000736974 cites W2809092342 @default.
- W3000736974 cites W2874653366 @default.
- W3000736974 cites W2885573416 @default.
- W3000736974 cites W2887292446 @default.
- W3000736974 cites W2908433735 @default.
- W3000736974 cites W2910213537 @default.
- W3000736974 cites W2913826244 @default.
- W3000736974 cites W2921536182 @default.
- W3000736974 cites W2923350365 @default.
- W3000736974 cites W2948768009 @default.
- W3000736974 cites W2949207210 @default.