FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000763513> ?p ?o ?g. }

• W3000763513 endingPage "9" @default.
• W3000763513 startingPage "1" @default.
• W3000763513 abstract "ABSTRACT The antigen binding variable domain (VNAR) of the shark immunoglobulin new antigen receptor (IgNAR) evolved approximately 500 million years ago and it is one of the smallest antibody fragments in the animal kingdom with sizes of 12–15 kDa. This review discusses the current knowledge of the shark VNAR single domain sequences and ongoing development of shark VNARs as research tools as well as potential therapeutics, in particular highlighting the recent next-generation sequencing analysis of 1.2 million shark VNAR sequences and construction of a large phage displayed shark VNAR library from six naïve adult nurse sharks (Ginglymostoma cirratum). The large phage-displayed VNAR single domain library covers all the four known VNAR types (Types I–IV) and many previously unknown types. Ongoing preclinical development will help define the utility of shark VNAR single domains as a potentially new family of drug candidates for treating cancer and other human diseases." @default.
• W3000763513 created "2020-01-30" @default.
• W3000763513 creator A5036066519 @default.
• W3000763513 creator A5065232582 @default.
• W3000763513 creator A5091769570 @default.
• W3000763513 date "2020-01-01" @default.
• W3000763513 modified "2023-10-14" @default.
• W3000763513 title "Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applications" @default.
• W3000763513 cites W116895358 @default.
• W3000763513 cites W1481978003 @default.
• W3000763513 cites W1494411030 @default.
• W3000763513 cites W1972394228 @default.
• W3000763513 cites W1978217631 @default.
• W3000763513 cites W1981116599 @default.
• W3000763513 cites W1981853922 @default.
• W3000763513 cites W1991888686 @default.
• W3000763513 cites W1998494295 @default.
• W3000763513 cites W2021256658 @default.
• W3000763513 cites W2023485491 @default.
• W3000763513 cites W2027972989 @default.
• W3000763513 cites W2033078275 @default.
• W3000763513 cites W2033236533 @default.
• W3000763513 cites W2037042031 @default.
• W3000763513 cites W2042720435 @default.
• W3000763513 cites W2045346799 @default.
• W3000763513 cites W2056392188 @default.
• W3000763513 cites W2058388773 @default.
• W3000763513 cites W2058492852 @default.
• W3000763513 cites W2063712078 @default.
• W3000763513 cites W2072902418 @default.
• W3000763513 cites W2074015830 @default.
• W3000763513 cites W2078923745 @default.
• W3000763513 cites W2083986573 @default.
• W3000763513 cites W2092559826 @default.
• W3000763513 cites W2115662814 @default.
• W3000763513 cites W2115912680 @default.
• W3000763513 cites W2120929471 @default.
• W3000763513 cites W2140060739 @default.
• W3000763513 cites W2151197219 @default.
• W3000763513 cites W2160086029 @default.
• W3000763513 cites W2160813629 @default.
• W3000763513 cites W2167918070 @default.
• W3000763513 cites W2169236651 @default.
• W3000763513 cites W2398491620 @default.
• W3000763513 cites W240703769 @default.
• W3000763513 cites W2465407223 @default.
• W3000763513 cites W2504337473 @default.
• W3000763513 cites W2739323872 @default.
• W3000763513 cites W2758511152 @default.
• W3000763513 cites W2765708508 @default.
• W3000763513 cites W2778983584 @default.
• W3000763513 cites W2790505494 @default.
• W3000763513 cites W2790876771 @default.
• W3000763513 cites W2794712838 @default.
• W3000763513 cites W2809221957 @default.
• W3000763513 cites W2890955636 @default.
• W3000763513 cites W2898090990 @default.
• W3000763513 cites W2899056157 @default.
• W3000763513 cites W2899623314 @default.
• W3000763513 cites W2914695641 @default.
• W3000763513 cites W2916798890 @default.
• W3000763513 cites W2922801360 @default.
• W3000763513 cites W2935751411 @default.
• W3000763513 cites W2949741173 @default.
• W3000763513 cites W2982689442 @default.
• W3000763513 cites W4365405431 @default.
• W3000763513 doi "https://doi.org/10.1093/abt/tbaa001" @default.
• W3000763513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7034638" @default.
• W3000763513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32118195" @default.
• W3000763513 hasPublicationYear "2020" @default.
• W3000763513 type Work @default.
• W3000763513 sameAs 3000763513 @default.
• W3000763513 citedByCount "28" @default.
• W3000763513 countsByYear W30007635132020 @default.
• W3000763513 countsByYear W30007635132021 @default.
• W3000763513 countsByYear W30007635132022 @default.
• W3000763513 countsByYear W30007635132023 @default.
• W3000763513 crossrefType "journal-article" @default.
• W3000763513 hasAuthorship W3000763513A5036066519 @default.
• W3000763513 hasAuthorship W3000763513A5065232582 @default.
• W3000763513 hasAuthorship W3000763513A5091769570 @default.
• W3000763513 hasBestOaLocation W30007635131 @default.
• W3000763513 hasConcept C134306372 @default.
• W3000763513 hasConcept C147483822 @default.
• W3000763513 hasConcept C159654299 @default.
• W3000763513 hasConcept C186268636 @default.
• W3000763513 hasConcept C2777820669 @default.
• W3000763513 hasConcept C33923547 @default.
• W3000763513 hasConcept C36503486 @default.
• W3000763513 hasConcept C54355233 @default.
• W3000763513 hasConcept C60644358 @default.
• W3000763513 hasConcept C70721500 @default.
• W3000763513 hasConcept C74187038 @default.
• W3000763513 hasConcept C86803240 @default.
• W3000763513 hasConceptScore W3000763513C134306372 @default.
• W3000763513 hasConceptScore W3000763513C147483822 @default.
• W3000763513 hasConceptScore W3000763513C159654299 @default.
• W3000763513 hasConceptScore W3000763513C186268636 @default.

• next