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- W3000797409 abstract "Chordomas are benign, highly recurrent tumors of the midline skeleton that arise from the remnants of the notochord. The development of systemic therapy is critically important to ultimately managing this tumor. Several ongoing trials are attempting to use molecular targeted therapies for mutated pathways in recurrent and advanced chordomas and have shown promise. In addition, immunotherapies, including brachyury-directed vaccination and checkpoint inhibition, have also been attempted with encouraging results. This article discusses the major pathways that have been implicated in the pathogenesis of chordoma with an emphasis on molecular vulnerabilities that future therapies are attempting to exploit." @default.
- W3000797409 created "2020-01-30" @default.
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- W3000797409 date "2020-04-01" @default.
- W3000797409 modified "2023-10-16" @default.
- W3000797409 title "New Prospects for Molecular Targets for Chordomas" @default.
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- W3000797409 doi "https://doi.org/10.1016/j.nec.2019.11.004" @default.
- W3000797409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7374924" @default.
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