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• W3000832251 abstract "Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Interleukin-1 β is the key player in the pathogenesis of OA, which induces the expression of various catabolic factors that contribute to cartilage degradation. Cynaroside (luteolin-7-O-glucoside or luteoloside) is a flavonoid that has various pharmacological properties, such as antitumor, anti-inflammatory, and antioxidant activities. In this study, we investigated the chondroprotective effects of cynaroside on IL-1 β -stimulated chondrocytes and organ explants. The production of nitrite, PGE 2 , collagen type II, and aggrecan was measured by a Griess reagent and ELISAs, and the production of ROS was measured by H 2 DCF-DA fluorescence. The protein levels of iNOS, Cox-2, MMP-1, MMP-3, MMP-13, ADAMTS-4, MAPKs, and the NF- κ B p65 subunit were measured by western blot. Proteoglycan analysis was performed by Alcian Blue staining ( in vitro ) and Safranin O staining ( ex vivo ). Cynaroside inhibited IL-1 β -induced expression of catabolic factors (nitrite, iNOS, ROS, PGE 2 , Cox-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4) and degradation of anabolic factors (collagen type II and aggrecan). Furthermore, cynaroside suppressed IL-1 β -induced phosphorylation of MAPKs and translocation of the NF- κ B p65 subunit into the nucleus. Collectively, these results suggest that cynaroside may be a potential candidate for the development of new therapeutic drugs for the alleviation of OA progression." @default.
• W3000832251 created "2020-01-30" @default.
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• W3000832251 date "2020-01-25" @default.
• W3000832251 modified "2023-10-17" @default.
• W3000832251 title "Chondroprotective Effect of Cynaroside in IL-1<i>β</i>-Induced Primary Rat Chondrocytes and Organ Explants via NF-<i>κ</i>B and MAPK Signaling Inhibition" @default.
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• W3000832251 doi "https://doi.org/10.1155/2020/9358080" @default.
• W3000832251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7003268" @default.
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