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- W3000852078 abstract "WHO hepatitis B (HbsAg) guidelines recommend testing all new HIV patients, treating them accordingly or providing immunization. At the Infectious Diseases Institute (IDI) following an audit done in 2012, only 46% patients had been screened for HbsAg with variable management plans therefore new internal guidelines were implemented. This study describes the uptake of HbsAg screening and management of patients with HbsAg and HIV con-infection after the implementation. Data included for all HIV positive patients in care at IDI by October 2015. Data are expressed as median with interquartile range (IQR) and percentages were compared using the chi square test.Statistical analysis was performed using STATA version 13.The IDI laboratory upper limit of normal for alanine aminotransferase (ALT) and aspartate aminotransferase (ASTs) was 40 IU/ml. Number of HbsAg tests done increased from 800 in 2012 to 1400 in 2015 with a total of, 8042/8604(93.5%) patients screened . Overall HbsAg positive were; 359 (4.6%), male 189 (52.6%), median age 38 (32, 45), on ART337 (93.9%) with a median time on ART 74 (27, 399) days.166 (81.4%) HbsAg positives were switched to a Tenofovir containing regimen. Of those not switched, 8(36.4%) died, 4(18.2%) discontinued care, 7(31.8%) had been transferred out. Overall 23 (6.5%) HbsAg positives died. Patients with ASTs done were 86(24%), 7(1.9%) had HbsAg viral loads and 250(69.6%) patients with an ultra sound scan done. Our study confirms the importance of screening for HbsAg and of using ART regimens containing Tenofovir in HbsAg co-infected patients. Whilst our program has made improvements in care still 18.6% of patients with HbsAg were not on Tenofovir regimens, 98.1% had no HbsAg viral loads done. Clinicians should recognize the potential for HbsAg in HIV positive patients and the importance of early diagnosis and treatment to ensure optimal management of cases and follow up." @default.
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- W3000852078 date "2016-11-01" @default.
- W3000852078 modified "2023-09-30" @default.
- W3000852078 title "Uptake of Hepatitis B HIV Co-Infection Screening And Management In A Resource Limited Setting" @default.
- W3000852078 doi "https://doi.org/10.1016/j.jval.2016.09.1481" @default.
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