Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000889276> ?p ?o ?g. }
- W3000889276 endingPage "13" @default.
- W3000889276 startingPage "1" @default.
- W3000889276 abstract "To identify noninvasive immune biomarkers of exercise-induced immunosuppression using the iTRAQ proteomics technique.Fifteen healthy males were recruited and subjected to a four-week incremental treadmill running training program. After each week of training, WBC counts and CD4+ and CD8+ lymphocytes were measured to monitor the immune function status. iTRAQ proteomics technology was used to identify differential proteins and their characteristics in urine.Our data showed that the WBC counts, CD4+ lymphocytes, and CD4+/CD8+ ratio decreased by more than 10% after four weeks of training, suggesting exercise-induced immunosuppression. A total of 1854 proteins were identified in urine during the incremental running using the iTRAQ technology. Compared with the urine before training, there were 89, 52, 77, and 148 proteins significantly upregulated and 66, 27, 68, and 114 proteins significantly downregulated after each week, respectively. Among them, four upregulated proteins, SEMG-1, PIP, PDGFRL, and NDPK, increased their abundance with the increased exercise intensity. Bioinformatics analysis indicates that these proteins are involved in stress response and immune function.Four weeks of incremental treadmill running induced immunosuppression in healthy males. By using iTRAQ proteomics, four proteins in the urine, SEMG-1, PIP, PDGFRL, and NDPK, were found to increase incrementally with the increased exercise intensity, which have the potential to be used as noninvasive immune biomarkers of exercise-induced immunosuppression." @default.
- W3000889276 created "2020-01-30" @default.
- W3000889276 creator A5016793412 @default.
- W3000889276 creator A5059387655 @default.
- W3000889276 creator A5065561636 @default.
- W3000889276 creator A5072438559 @default.
- W3000889276 creator A5088475003 @default.
- W3000889276 date "2020-01-25" @default.
- W3000889276 modified "2023-09-23" @default.
- W3000889276 title "Identification of Urinary Biomarkers for Exercise-Induced Immunosuppression by iTRAQ Proteomics" @default.
- W3000889276 cites W1030850681 @default.
- W3000889276 cites W1122051145 @default.
- W3000889276 cites W112997920 @default.
- W3000889276 cites W1219473977 @default.
- W3000889276 cites W142759255 @default.
- W3000889276 cites W1480297753 @default.
- W3000889276 cites W1491848125 @default.
- W3000889276 cites W1532673576 @default.
- W3000889276 cites W1575453988 @default.
- W3000889276 cites W1679786555 @default.
- W3000889276 cites W1779444278 @default.
- W3000889276 cites W1804596790 @default.
- W3000889276 cites W1966862542 @default.
- W3000889276 cites W1967556066 @default.
- W3000889276 cites W1974361254 @default.
- W3000889276 cites W1983688130 @default.
- W3000889276 cites W1986056515 @default.
- W3000889276 cites W1987449662 @default.
- W3000889276 cites W1990997193 @default.
- W3000889276 cites W1991286636 @default.
- W3000889276 cites W1993341011 @default.
- W3000889276 cites W1996782754 @default.
- W3000889276 cites W2006451718 @default.
- W3000889276 cites W2007774958 @default.
- W3000889276 cites W2011807125 @default.
- W3000889276 cites W2015169110 @default.
- W3000889276 cites W2016008005 @default.
- W3000889276 cites W2020700357 @default.
- W3000889276 cites W2020982108 @default.
- W3000889276 cites W2021149804 @default.
- W3000889276 cites W2021319115 @default.
- W3000889276 cites W2022749572 @default.
- W3000889276 cites W2023411705 @default.
- W3000889276 cites W2034877464 @default.
- W3000889276 cites W2042794878 @default.
- W3000889276 cites W2048876958 @default.
- W3000889276 cites W2050712934 @default.
- W3000889276 cites W2053694100 @default.
- W3000889276 cites W2054283948 @default.
- W3000889276 cites W2060222428 @default.
- W3000889276 cites W2062365656 @default.
- W3000889276 cites W2063001525 @default.
- W3000889276 cites W2063538217 @default.
- W3000889276 cites W2067025461 @default.
- W3000889276 cites W2074022831 @default.
- W3000889276 cites W2077384664 @default.
- W3000889276 cites W2077633980 @default.
- W3000889276 cites W2084130689 @default.
- W3000889276 cites W2088309435 @default.
- W3000889276 cites W2093995942 @default.
- W3000889276 cites W2096173332 @default.
- W3000889276 cites W2098057749 @default.
- W3000889276 cites W2103662370 @default.
- W3000889276 cites W2105924489 @default.
- W3000889276 cites W2107037784 @default.
- W3000889276 cites W2107681355 @default.
- W3000889276 cites W2113654582 @default.
- W3000889276 cites W2119197472 @default.
- W3000889276 cites W2129023649 @default.
- W3000889276 cites W2135659687 @default.
- W3000889276 cites W2138935020 @default.
- W3000889276 cites W2154209322 @default.
- W3000889276 cites W2168011657 @default.
- W3000889276 cites W2306509029 @default.
- W3000889276 cites W2332752443 @default.
- W3000889276 cites W2395607087 @default.
- W3000889276 cites W2404768398 @default.
- W3000889276 cites W2424331829 @default.
- W3000889276 cites W2441999943 @default.
- W3000889276 cites W2463198732 @default.
- W3000889276 cites W2463787296 @default.
- W3000889276 cites W2480975978 @default.
- W3000889276 cites W2486930925 @default.
- W3000889276 cites W2519388710 @default.
- W3000889276 cites W25368323 @default.
- W3000889276 cites W2579927750 @default.
- W3000889276 cites W2581177295 @default.
- W3000889276 cites W2583989542 @default.
- W3000889276 cites W2589111289 @default.
- W3000889276 cites W2593892406 @default.
- W3000889276 cites W2606936479 @default.
- W3000889276 cites W2777180627 @default.
- W3000889276 cites W2791961651 @default.
- W3000889276 cites W2796541253 @default.
- W3000889276 cites W2803858221 @default.
- W3000889276 cites W2914829928 @default.
- W3000889276 cites W314441787 @default.
- W3000889276 doi "https://doi.org/10.1155/2020/3030793" @default.