Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000953621> ?p ?o ?g. }
- W3000953621 abstract "Abstract Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipogenic signaling and suppression of lipid metabolic pathways. The expression of proteins responsible for lipogenesis was down regulated. The membrane permeability and functionality of PCa were severely affected and caused nuclear disorganization during drug exposure. Finally, these consolidated events shifted the cell’s survival balance towards apoptosis. These results suggest that TA distinctly interferes with the lipid signaling and metabolism of PCa cells." @default.
- W3000953621 created "2020-01-30" @default.
- W3000953621 creator A5010537412 @default.
- W3000953621 creator A5013641421 @default.
- W3000953621 creator A5015637677 @default.
- W3000953621 creator A5024010152 @default.
- W3000953621 creator A5024630635 @default.
- W3000953621 creator A5034011054 @default.
- W3000953621 creator A5035778593 @default.
- W3000953621 creator A5041474939 @default.
- W3000953621 creator A5063635992 @default.
- W3000953621 date "2020-01-22" @default.
- W3000953621 modified "2023-10-13" @default.
- W3000953621 title "Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells" @default.
- W3000953621 cites W1182447099 @default.
- W3000953621 cites W1540505497 @default.
- W3000953621 cites W1627885886 @default.
- W3000953621 cites W1822921369 @default.
- W3000953621 cites W1950405118 @default.
- W3000953621 cites W1963762892 @default.
- W3000953621 cites W1973064781 @default.
- W3000953621 cites W1976920897 @default.
- W3000953621 cites W1986234170 @default.
- W3000953621 cites W1990581716 @default.
- W3000953621 cites W1993207934 @default.
- W3000953621 cites W1996067792 @default.
- W3000953621 cites W2002746961 @default.
- W3000953621 cites W2015671755 @default.
- W3000953621 cites W2025639892 @default.
- W3000953621 cites W2025884506 @default.
- W3000953621 cites W2027072290 @default.
- W3000953621 cites W2027443731 @default.
- W3000953621 cites W2028331007 @default.
- W3000953621 cites W2030238672 @default.
- W3000953621 cites W2034109502 @default.
- W3000953621 cites W2040905261 @default.
- W3000953621 cites W2044433516 @default.
- W3000953621 cites W2048405357 @default.
- W3000953621 cites W2066411725 @default.
- W3000953621 cites W2067562513 @default.
- W3000953621 cites W2072495277 @default.
- W3000953621 cites W2079995225 @default.
- W3000953621 cites W2093535002 @default.
- W3000953621 cites W2097502797 @default.
- W3000953621 cites W2101861123 @default.
- W3000953621 cites W2103023937 @default.
- W3000953621 cites W2108087391 @default.
- W3000953621 cites W2109424117 @default.
- W3000953621 cites W2133275245 @default.
- W3000953621 cites W2135546443 @default.
- W3000953621 cites W2139084975 @default.
- W3000953621 cites W2143657346 @default.
- W3000953621 cites W2147328441 @default.
- W3000953621 cites W2152311269 @default.
- W3000953621 cites W2160878339 @default.
- W3000953621 cites W2190152841 @default.
- W3000953621 cites W2228249985 @default.
- W3000953621 cites W2265836483 @default.
- W3000953621 cites W2270766610 @default.
- W3000953621 cites W2281135663 @default.
- W3000953621 cites W2324631901 @default.
- W3000953621 cites W2331772202 @default.
- W3000953621 cites W2338192894 @default.
- W3000953621 cites W2344000214 @default.
- W3000953621 cites W2398571480 @default.
- W3000953621 cites W2469942742 @default.
- W3000953621 cites W2507638513 @default.
- W3000953621 cites W2520395051 @default.
- W3000953621 cites W2521574223 @default.
- W3000953621 cites W2526190858 @default.
- W3000953621 cites W2540015046 @default.
- W3000953621 cites W2547942905 @default.
- W3000953621 cites W2559423762 @default.
- W3000953621 cites W2579992989 @default.
- W3000953621 cites W2580445561 @default.
- W3000953621 cites W2587657917 @default.
- W3000953621 cites W2588583241 @default.
- W3000953621 cites W2698350175 @default.
- W3000953621 cites W2727689036 @default.
- W3000953621 cites W2773871562 @default.
- W3000953621 cites W2781525129 @default.
- W3000953621 cites W2782004408 @default.
- W3000953621 cites W2790084239 @default.
- W3000953621 cites W2793605053 @default.
- W3000953621 cites W2800510790 @default.
- W3000953621 cites W2803933285 @default.
- W3000953621 cites W2810176492 @default.
- W3000953621 cites W2885636673 @default.
- W3000953621 cites W2889551461 @default.
- W3000953621 cites W2892069171 @default.
- W3000953621 cites W2892565790 @default.
- W3000953621 cites W2900692081 @default.
- W3000953621 cites W2905420827 @default.
- W3000953621 cites W2911508682 @default.
- W3000953621 cites W2972632416 @default.
- W3000953621 cites W2976684613 @default.
- W3000953621 doi "https://doi.org/10.1038/s41598-020-57932-9" @default.
- W3000953621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6976712" @default.
- W3000953621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31969643" @default.
- W3000953621 hasPublicationYear "2020" @default.