FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000961888> ?p ?o ?g. }

• W3000961888 abstract "Abstract Background Cell‐free microRNAs (miRs) have emerged as early and sensitive biomarkers for tissue injury and function. This study aimed to investigate whether the release of hepatocyte‐derived microRNAs (HDmiRs) and cholangiocyte‐derived miRs (CDmiRs) correlates with hepato‐cholangiocellular injury and function during oxygenated, normothermic machine perfusion (NMP) of human liver grafts. Methods Donor livers (n = 12), declined for transplantation, were subjected to oxygenated NMP (6 hours) after a period of static cold storage (median 544 minutes (IQR 421‐674)). Perfusate and bile samples were analyzed by qRT‐PCR for HDmiR‐122 and CDmiR‐222. Spearman correlations were performed between miR levels and currently available indicators and classic markers. Results Both HDmiR‐122 and CDmiR‐222 levels in perfusate at 30 minutes of NMP strongly correlated with hepatocyte injury (peak perfusate AST) and cholangiocyte injury (peak biliary LDH). In bile, only CDmiR‐222 correlated with these injury markers. For hepato‐cholangiocellular function, both miRs in perfusate correlated with total bilirubin, while HDmiR‐122 (in perfusate) and CDmiR‐222 (in bile) correlated with bicarbonate secretion. Both the relative ratio of HDmiR‐122/CDmiR‐222 and AST in perfusate at 30 minutes significantly correlated with cumulative bile production, but only the relative ratio was predictive of histopathological injury after 6 hours NMP. Conclusion Early levels of HDmiR‐122 and CDmiR‐222, in perfusate and/or bile, are predictive of excretory functions and hepato‐cholangiocellular injury after 6 hours NMP. These miRs may represent new biomarkers for graft viability and function during machine perfusion." @default.
• W3000961888 created "2020-01-30" @default.
• W3000961888 creator A5005270865 @default.
• W3000961888 creator A5046096257 @default.
• W3000961888 creator A5048946142 @default.
• W3000961888 creator A5050983857 @default.
• W3000961888 creator A5055556726 @default.
• W3000961888 creator A5069191206 @default.
• W3000961888 creator A5082702179 @default.
• W3000961888 creator A5086856138 @default.
• W3000961888 date "2020-02-20" @default.
• W3000961888 modified "2023-09-30" @default.
• W3000961888 title "Cell‐free microRNAs as early predictors of graft viability during ex vivo normothermic machine perfusion of human donor livers" @default.
• W3000961888 cites W1577577364 @default.
• W3000961888 cites W1592491502 @default.
• W3000961888 cites W162447880 @default.
• W3000961888 cites W1942586052 @default.
• W3000961888 cites W1968008181 @default.
• W3000961888 cites W1976599828 @default.
• W3000961888 cites W1979601962 @default.
• W3000961888 cites W1991109323 @default.
• W3000961888 cites W2009371120 @default.
• W3000961888 cites W2016525674 @default.
• W3000961888 cites W2044871251 @default.
• W3000961888 cites W2050387987 @default.
• W3000961888 cites W2054984901 @default.
• W3000961888 cites W2059117644 @default.
• W3000961888 cites W2061498960 @default.
• W3000961888 cites W2082924948 @default.
• W3000961888 cites W2129991742 @default.
• W3000961888 cites W2156190695 @default.
• W3000961888 cites W2161163389 @default.
• W3000961888 cites W2233914793 @default.
• W3000961888 cites W2265986208 @default.
• W3000961888 cites W2312592879 @default.
• W3000961888 cites W2332807430 @default.
• W3000961888 cites W2408513784 @default.
• W3000961888 cites W2497103560 @default.
• W3000961888 cites W2510207072 @default.
• W3000961888 cites W2521365511 @default.
• W3000961888 cites W2568925976 @default.
• W3000961888 cites W2605184493 @default.
• W3000961888 cites W2607151813 @default.
• W3000961888 cites W2632303233 @default.
• W3000961888 cites W2788057351 @default.
• W3000961888 cites W2794134218 @default.
• W3000961888 cites W2797665619 @default.
• W3000961888 cites W2810974654 @default.
• W3000961888 cites W2898560828 @default.
• W3000961888 cites W2898923803 @default.
• W3000961888 cites W2967264496 @default.
• W3000961888 cites W2968222209 @default.
• W3000961888 doi "https://doi.org/10.1111/ctr.13790" @default.
• W3000961888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7154637" @default.
• W3000961888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31984571" @default.
• W3000961888 hasPublicationYear "2020" @default.
• W3000961888 type Work @default.
• W3000961888 sameAs 3000961888 @default.
• W3000961888 citedByCount "15" @default.
• W3000961888 countsByYear W30009618882020 @default.
• W3000961888 countsByYear W30009618882021 @default.
• W3000961888 countsByYear W30009618882022 @default.
• W3000961888 countsByYear W30009618882023 @default.
• W3000961888 crossrefType "journal-article" @default.
• W3000961888 hasAuthorship W3000961888A5005270865 @default.
• W3000961888 hasAuthorship W3000961888A5046096257 @default.
• W3000961888 hasAuthorship W3000961888A5048946142 @default.
• W3000961888 hasAuthorship W3000961888A5050983857 @default.
• W3000961888 hasAuthorship W3000961888A5055556726 @default.
• W3000961888 hasAuthorship W3000961888A5069191206 @default.
• W3000961888 hasAuthorship W3000961888A5082702179 @default.
• W3000961888 hasAuthorship W3000961888A5086856138 @default.
• W3000961888 hasBestOaLocation W30009618881 @default.
• W3000961888 hasConcept C126322002 @default.
• W3000961888 hasConcept C142724271 @default.
• W3000961888 hasConcept C146957229 @default.
• W3000961888 hasConcept C150903083 @default.
• W3000961888 hasConcept C16685009 @default.
• W3000961888 hasConcept C202751555 @default.
• W3000961888 hasConcept C207001950 @default.
• W3000961888 hasConcept C26291073 @default.
• W3000961888 hasConcept C2776200302 @default.
• W3000961888 hasConcept C2776637226 @default.
• W3000961888 hasConcept C2779288732 @default.
• W3000961888 hasConcept C2779609443 @default.
• W3000961888 hasConcept C2780186670 @default.
• W3000961888 hasConcept C2911091166 @default.
• W3000961888 hasConcept C2992208098 @default.
• W3000961888 hasConcept C55493867 @default.
• W3000961888 hasConcept C71924100 @default.
• W3000961888 hasConcept C86803240 @default.
• W3000961888 hasConcept C90924648 @default.
• W3000961888 hasConceptScore W3000961888C126322002 @default.
• W3000961888 hasConceptScore W3000961888C142724271 @default.
• W3000961888 hasConceptScore W3000961888C146957229 @default.
• W3000961888 hasConceptScore W3000961888C150903083 @default.
• W3000961888 hasConceptScore W3000961888C16685009 @default.
• W3000961888 hasConceptScore W3000961888C202751555 @default.
• W3000961888 hasConceptScore W3000961888C207001950 @default.
• W3000961888 hasConceptScore W3000961888C26291073 @default.

• next