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- W3000965667 abstract "Hepatitis C virus (HCV) persists asymptomatically in the majority of infected individuals and is strongly associated with chronic hepatitis, hepatic steatosis, cirrhosis, and hepatocellular carcinoma. Unlike interferon or ribavirin, direct-acting antivirals specifically target nonstructural proteins, such as the NS3/NS4A serine protease, the nonstructural protein 5A (NS5A), or the HCV polymerase (NS5B), leading to inhibition of HCV RNA replication and infection. NS5A has been implicated as a modulator of critical viral functions including facilitation of viral RNA replication, virus assembly, transport and release, as well as regulator of the antiviral interferon response. Clinically relevant NS5B inhibitors are classified as non-nucleoside inhibitors and nucleotide inhibitors that act at distinct stages of RNA synthesis. Finally, sofosbuvir and other nucleoside HCV polymerase inhibitors have been shown to inhibit replication of various viruses such as zika, dengue, and norovirus." @default.
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- W3000965667 date "2020-01-24" @default.
- W3000965667 modified "2023-10-17" @default.
- W3000965667 title "Nucleoside Antiviral Agents for HCV" @default.
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- W3000965667 doi "https://doi.org/10.1002/9781119436812.ch67" @default.
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