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- W3000998630 abstract "Abstract The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s) of action remains unknown. We previously characterized rats hemi-intranigrally injected with the proteasomal inhibitor lactacystin, as an accurate preclinical model of PD. Here we used a combination of chemogenetics with positron emission tomography imaging for in vivo interrogation of discrete neural networks in this rat model of PD. Stimulation of excitatory designer receptors exclusively activated by designer drugs expressed within PPN cholinergic neurons activated residual nigrostriatal dopaminergic neurons to produce profound motor recovery, which correlated with striatal dopamine efflux as well as restored dopamine receptor 1- and dopamine receptor 2-based medium spiny neuron activity, as was ascertained with c-Fos-based immunohistochemistry and stereological cell counts. By revealing that the improved axial-related motor functions seen in PD patients receiving PPN-DBS may be due to stimulation of remaining PPN cholinergic neurons interacting with dopaminergic ones in both the substantia nigra pars compacta and the striatum, our data strongly favor the PPN cholinergic–midbrain dopaminergic connectome as mechanism for PPN-DBS’s therapeutic effects. These findings have implications for refining PPN-DBS as a promising treatment modality available to PD patients." @default.
- W3000998630 created "2020-01-30" @default.
- W3000998630 creator A5005098704 @default.
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- W3000998630 creator A5065399413 @default.
- W3000998630 creator A5069326318 @default.
- W3000998630 date "2020-01-21" @default.
- W3000998630 modified "2023-09-25" @default.
- W3000998630 title "DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats" @default.
- W3000998630 cites W111152228 @default.
- W3000998630 cites W1583292806 @default.
- W3000998630 cites W1681161665 @default.
- W3000998630 cites W1809669268 @default.
- W3000998630 cites W1900959016 @default.
- W3000998630 cites W1963963248 @default.
- W3000998630 cites W1966417447 @default.
- W3000998630 cites W1967139897 @default.
- W3000998630 cites W1970514569 @default.
- W3000998630 cites W197750504 @default.
- W3000998630 cites W1981420707 @default.
- W3000998630 cites W1981609060 @default.
- W3000998630 cites W1986214786 @default.
- W3000998630 cites W1990052754 @default.
- W3000998630 cites W1991603311 @default.
- W3000998630 cites W1998290119 @default.
- W3000998630 cites W2004329345 @default.
- W3000998630 cites W2009807412 @default.
- W3000998630 cites W2024970998 @default.
- W3000998630 cites W2025546312 @default.
- W3000998630 cites W2028144985 @default.
- W3000998630 cites W2028619376 @default.
- W3000998630 cites W2037155998 @default.
- W3000998630 cites W2038636807 @default.
- W3000998630 cites W2039208144 @default.
- W3000998630 cites W2040462710 @default.
- W3000998630 cites W2042348810 @default.
- W3000998630 cites W2043886102 @default.
- W3000998630 cites W2045873213 @default.
- W3000998630 cites W2048779384 @default.
- W3000998630 cites W2051274411 @default.
- W3000998630 cites W2051363333 @default.
- W3000998630 cites W2053623501 @default.
- W3000998630 cites W2056834932 @default.
- W3000998630 cites W2060810779 @default.
- W3000998630 cites W2063741375 @default.
- W3000998630 cites W2068881405 @default.
- W3000998630 cites W2069072617 @default.
- W3000998630 cites W2069323051 @default.
- W3000998630 cites W2069441590 @default.
- W3000998630 cites W2071248098 @default.
- W3000998630 cites W2072099227 @default.
- W3000998630 cites W2073769248 @default.
- W3000998630 cites W2081301348 @default.
- W3000998630 cites W2082778628 @default.
- W3000998630 cites W2084576299 @default.
- W3000998630 cites W2084615691 @default.
- W3000998630 cites W2084621470 @default.
- W3000998630 cites W2087801790 @default.
- W3000998630 cites W2089752756 @default.
- W3000998630 cites W2091449711 @default.
- W3000998630 cites W2092042225 @default.
- W3000998630 cites W2092951039 @default.
- W3000998630 cites W2094367357 @default.
- W3000998630 cites W2104004822 @default.
- W3000998630 cites W2104702757 @default.
- W3000998630 cites W2106449410 @default.
- W3000998630 cites W2107574028 @default.
- W3000998630 cites W2109154368 @default.
- W3000998630 cites W2112350473 @default.
- W3000998630 cites W2115116088 @default.
- W3000998630 cites W2120197531 @default.
- W3000998630 cites W2121379737 @default.
- W3000998630 cites W2128627087 @default.
- W3000998630 cites W2136193649 @default.
- W3000998630 cites W2138166961 @default.
- W3000998630 cites W2145550365 @default.
- W3000998630 cites W2147702204 @default.
- W3000998630 cites W2151885529 @default.
- W3000998630 cites W2158590037 @default.
- W3000998630 cites W2165909414 @default.
- W3000998630 cites W2172085609 @default.
- W3000998630 cites W2269754795 @default.
- W3000998630 cites W2484015429 @default.
- W3000998630 cites W2549716181 @default.
- W3000998630 cites W269955399 @default.
- W3000998630 cites W2741917192 @default.
- W3000998630 cites W2745223669 @default.
- W3000998630 cites W2770519439 @default.
- W3000998630 cites W2773681110 @default.
- W3000998630 cites W2776282735 @default.
- W3000998630 cites W2804376135 @default.
- W3000998630 cites W2885396450 @default.
- W3000998630 cites W2978264177 @default.