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• W3001031567 abstract "A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm. The most active tetraoxane, compound LC140, exhibited an IC50 value of 2.52 ± 0.65 µm on L. donovani intramacrophage amastigotes, with a selectivity index of 13.5. This compound reduced the liver parasite burden of L. donovani-infected mice by 37% after an intraperitoneal treatment at 10 mg/kg/day for five consecutive days, whereas miltefosine, an antileishmanial drug in use, reduced it by 66%. These results provide a relevant basis for the development of further tetraoxanes as effective, safe, and cheap drugs against leishmaniasis." @default.
• W3001031567 created "2020-01-30" @default.
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• W3001031567 date "2020-01-22" @default.
• W3001031567 modified "2023-10-09" @default.
• W3001031567 title "Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani" @default.
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• W3001031567 doi "https://doi.org/10.3390/molecules25030465" @default.
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