Matches in SemOpenAlex for { <https://semopenalex.org/work/W3001036720> ?p ?o ?g. }
- W3001036720 endingPage "101443" @default.
- W3001036720 startingPage "101443" @default.
- W3001036720 abstract "The abnormal inflammatory responses due to the lung tissue damage and ineffective repair/resolution in response to the inhaled toxicants result in the pathological changes associated with chronic respiratory diseases. Investigation of such pathophysiological mechanisms provides the opportunity to develop the molecular phenotype-specific diagnostic assays and could help in designing the personalized medicine-based therapeutic approaches against these prevalent diseases. As the central hubs of cell metabolism and energetics, mitochondria integrate cellular responses and interorganellar signaling pathways to maintain cellular and extracellular redox status and the cellular senescence that dictate the lung tissue responses. Specifically, as observed in chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis, the mitochondria-endoplasmic reticulum (ER) crosstalk is disrupted by the inhaled toxicants such as the combustible and emerging electronic nicotine-delivery system (ENDS) tobacco products. Thus, the recent research efforts have focused on understanding how the mitochondria-ER dysfunctions and oxidative stress responses can be targeted to improve inflammatory and cellular dysfunctions associated with these pathologic illnesses that are exacerbated by viral infections. The present review assesses the importance of these redox signaling and cellular senescence pathways that describe the role of mitochondria and ER on the development and function of lung epithelial responses, highlighting the cause and effect associations that reflect the disease pathogenesis and possible intervention strategies." @default.
- W3001036720 created "2020-01-30" @default.
- W3001036720 creator A5005857171 @default.
- W3001036720 creator A5022090930 @default.
- W3001036720 creator A5036235908 @default.
- W3001036720 creator A5053157930 @default.
- W3001036720 creator A5058348723 @default.
- W3001036720 creator A5075972332 @default.
- W3001036720 creator A5078143948 @default.
- W3001036720 creator A5083113055 @default.
- W3001036720 creator A5089825865 @default.
- W3001036720 date "2020-06-01" @default.
- W3001036720 modified "2023-10-17" @default.
- W3001036720 title "Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases" @default.
- W3001036720 cites W122840989 @default.
- W3001036720 cites W1505898321 @default.
- W3001036720 cites W1522380508 @default.
- W3001036720 cites W1524845305 @default.
- W3001036720 cites W1546139069 @default.
- W3001036720 cites W1571416991 @default.
- W3001036720 cites W1586791826 @default.
- W3001036720 cites W1586820518 @default.
- W3001036720 cites W1843779691 @default.
- W3001036720 cites W1913038354 @default.
- W3001036720 cites W1939202796 @default.
- W3001036720 cites W1945197454 @default.
- W3001036720 cites W1965797097 @default.
- W3001036720 cites W1966252535 @default.
- W3001036720 cites W1966479831 @default.
- W3001036720 cites W1967388884 @default.
- W3001036720 cites W1967815590 @default.
- W3001036720 cites W1967992419 @default.
- W3001036720 cites W1973842058 @default.
- W3001036720 cites W1976391651 @default.
- W3001036720 cites W1979771795 @default.
- W3001036720 cites W1981120301 @default.
- W3001036720 cites W1987761030 @default.
- W3001036720 cites W1988048439 @default.
- W3001036720 cites W1991137866 @default.
- W3001036720 cites W1993559550 @default.
- W3001036720 cites W1998421163 @default.
- W3001036720 cites W2000084288 @default.
- W3001036720 cites W2000210076 @default.
- W3001036720 cites W2000960369 @default.
- W3001036720 cites W2002053621 @default.
- W3001036720 cites W2002198698 @default.
- W3001036720 cites W2004706975 @default.
- W3001036720 cites W2005357030 @default.
- W3001036720 cites W2005853038 @default.
- W3001036720 cites W2009001235 @default.
- W3001036720 cites W201150018 @default.
- W3001036720 cites W2014964914 @default.
- W3001036720 cites W2016823414 @default.
- W3001036720 cites W2019305446 @default.
- W3001036720 cites W2025077961 @default.
- W3001036720 cites W2025972928 @default.
- W3001036720 cites W2026289424 @default.
- W3001036720 cites W2029115864 @default.
- W3001036720 cites W2029532148 @default.
- W3001036720 cites W2034862563 @default.
- W3001036720 cites W2036156384 @default.
- W3001036720 cites W2037902955 @default.
- W3001036720 cites W2038500334 @default.
- W3001036720 cites W2043800250 @default.
- W3001036720 cites W2046065003 @default.
- W3001036720 cites W2046684143 @default.
- W3001036720 cites W2050308681 @default.
- W3001036720 cites W2051145352 @default.
- W3001036720 cites W2052959758 @default.
- W3001036720 cites W2055297290 @default.
- W3001036720 cites W2057813347 @default.
- W3001036720 cites W2058546920 @default.
- W3001036720 cites W2064182959 @default.
- W3001036720 cites W2065691491 @default.
- W3001036720 cites W2067406680 @default.
- W3001036720 cites W2068377942 @default.
- W3001036720 cites W2070721461 @default.
- W3001036720 cites W2072571019 @default.
- W3001036720 cites W2074115660 @default.
- W3001036720 cites W2074516296 @default.
- W3001036720 cites W2079335891 @default.
- W3001036720 cites W2089691992 @default.
- W3001036720 cites W2089933294 @default.
- W3001036720 cites W2102734197 @default.
- W3001036720 cites W2103334789 @default.
- W3001036720 cites W2103809903 @default.
- W3001036720 cites W2106051882 @default.
- W3001036720 cites W2106232279 @default.
- W3001036720 cites W2109882045 @default.
- W3001036720 cites W2110661586 @default.
- W3001036720 cites W2111732142 @default.
- W3001036720 cites W2112250552 @default.
- W3001036720 cites W2112658004 @default.
- W3001036720 cites W2113468396 @default.
- W3001036720 cites W2114263608 @default.
- W3001036720 cites W2118581168 @default.
- W3001036720 cites W2121709368 @default.
- W3001036720 cites W2122808445 @default.